Studies Toward Total Synthesis Of Linoxepin

This thesis focuses on the total synthesis of Linoxepin.It consists of the following three chapters.Chapter 1: This chapter mainly describes research progress on the synthesis of 7?-arylnaphthalene lignans so far,with an emphasis on unique strategies and methods.Chapter 2: Firstly,three total syntheses of Linoxepin were summarized.In my work,nickel-promoted reduction coupling developed by our laboratory was utilized to construct the the ?-lactone-fused tetrahydronaphthalene skeleton embedded in Linoxepin.However,there were some problems during the installation of B-ring,and further optimization is being investigated.Chapter 3: In this part,the second generation of the synthetic route for Linoxepin was disclosed,with a focus on the early-stage introduction of B-ring.This strategy was shown based on diaryl ketone and conjugate addition,respectively.The ccumulated experience in this invetigation will be beneficial to achieve the eventual synthesis of this molecule.