Synthesis Of 1,3-dipropargylimidazolidines And Oxazolidines With Multicomponent Reaction

Based on the principles of green chemistry,synthesis of 1,3-dipropargylimidazolidines and oxazolidines with multicomponent reaction were developed.A novel and efficient approach to the synthesis of 1,3-dipropargylimidazolidines via a heterodomino cyclization and copper-catalyzed double A3-coupling reaction of ethane-1,2-diamines,formaldehyde,and alkynes has been adopted herein.The transformation provides a useful method for the synthesis of imidazolidine derivatives.The reaction proceeded smoothly under base-,oxidant-and reductant-free conditions,and the raw materials are readily available.13 unreported imidazolidine derivatives were synthesized with this approach.A new multicomponent reaction of alcohol amine,formaldehyde and organic boric acid has been developed.The new method includes cyclization reaction,followed by a PBM reaction.The effects of different alcohols and substituent boric acid on the reaction process were investigated.The transformation provides a useful method for the synthesis of oxazolane derivatives,and was successfully applied to the preparation of 20 oxazolanes.