Rh(?)-catalyzed N-Chloroimine Directed And Oxazolone Directed C-H Activation For Cyclic Compounds Synthesis

Recently,Transition-metal-catalyzed cross-coupling has emerged as an effective strategy for chemical synthesis.Within this area,direct C-H bond transformation is one of the most efficient and environmentally friendly processes for the construction of new C-C or C-X bonds.Over the past decades,rhodium-catalyzed C-H functionalization has attracted considerable attention because of the versatility and wide use of rhodium catalysts in chemistry.Cp*Rh is one of the representative rhodium-base catalysts,which has been frequently reported.In order to realize the full potential of it,we need to explore the new directing groups,new coupling reagents,and mild reaction conditions,which provides a powerful synthetic method of natural products,pharmaceuticals or agrochemicals.In this paper,[RhCp*(CH3CN)3](SbF6)2-catalyzed N-chloroimine-directed C-H activation for synthesis of heterocycles has been discussed.And[Cp*RhCl2]2-catalyzed oxazolone-directed C-H activation for synthesis of cyclic compounds has also been discussed.The main contents include:In Chapter One,the research background of Rh-catalyzed C-H activation reactions and the synthesis of cyclic compounds in recent years was presented.In Chapter Two,we reported a method of[RhCp*(CH3CN)3](SbF6)2-catalyzed N-chloroimine directed C-H activation for synthesis of isoquinoline and its derivatives.Because of the broad substrate scope,we can incorporate a diverse range of substitution patterns into the isoquinoline scaffold,which has a large potential value for synthesizing pharmaceuticals.In Chapter Three,we reported a method of[Cp*RhCl2]2-catalyzed oxazolone-directed C-H activation for synthesis of spiro compoundands and its derivatives.Because of the broad substrate scope,we can incorporate a diverse range of substitution patterns into the spiro scaffold.