Rh(?)-Catalyzed C-H Activation For Heterocycles And Polyfunctional Synthesis

Transition metal catalyzed C-H activation has drawn much attention due to its good reactivity and step-economic in orangnic synthesis field.In this paper,rhodium combined with cyclopentadienyl(Cp*)catalyst is one of the representative transition metal catalyst,which has been warmly discussed before.Therefore,identifing new directing groups and collaborating with a varity of substrates is the key driving force for rhodium catalyst application.In this paper,we used[RhCp*C12]2 as catalyst to synthesize isoindole and salicylaldehyde products based on N-chloroimine and enaminone as directing groups.The main contents include:In Chapter One,a comparision of group 9[Cp*M?]catalysts was provided to discuss varied reactivities of three different mental(rhodium,cobalt,ruthenium)combined with cyclopentadienyl(Cp*)in C-H bond functionalization.In Chapter Two,the reaction of synthesizing isoindole with N-chloroimine as the directing group under the catalysis of Rh system was discussed.The reaction with varied substrates scope enabled a diverse range of substituents into desired products.Different from the synthesis before,the catalyst herein was lower,complicated reactions was avoided with dephosphorylation of phosphatidyl group of diazophosphates by N-Cl bond.In Chapter Three,the first time synthesis of salicylaldehydes via Rh(?)-catalyzed C-H bond activation has been reported.With the enaminone as the directing group,highly efficient,step-and atom-economic reaction has been achieved.Broad substrates scope enabled a wide range of products to be prepared for further academic and industrial purposes.