Construction Of Nanosupramolecular Systems Based On Polvfluoro Silicon(?) Phthalocyanine-Cvclodextrin And Its Controlled Releaseby Light Activation And Drug Competition

A series of polyfluorinatad silicon(?)phthalocyanine-cyclodeoxtrin nanosupramolecular systems had been constructed.Their structure were characterized and their photophysical properties were studied.The drug competition and light was used to control release of polyfluorinated silicon(?)phthalocyanine from nanosupramolecular systems were studied.A novel polyfluorosilicon(?)phthalocyanine was synthesized,and its the structure was characterized by 1H NMR,IR,ESI-MS,MALDL-TOF-MS and X-ray single crystal diffraction method.The photophysical properties and singlet oxygen quantum yield of polyfluorosilicon(?)phthalocyanine with non-polyfluoro silicon(?)phthalocyanine were compared by UV-Vis spectroscopy and fluorescence spectroscopy.The polysilicon(?)phthalocyanine(SiPc-F)and PEG-?-cyclodextrin(CM-?-CD-PEG)were self-assembled to form CM-?-CD-PEG-SiPc-F nanoparticles via host-guest reaction.The photophysical properties of CM-?-CD-PEG-SiPc-F nanoparticles were studied by UV-Vis and fluorescence spectra.The SiPc-F was released from CM-?-CD-PEG-SiPc-F nanoparticles by competition reaction with amantadine hydrochloride(1-ADH).A singlet wall carbon nanotube-pyrene-cyclodextrin-polysilicon phthalocyanine(SWNTs-p-CD-SiPc-F)nano-supramolecular system was constructed.The structure of SWNTs-p-CD-SiPc-F was characterization by transmission electron microscopy(TEM),infrared spectroscopy(IR),Raman spectroscopy(Raman),X-ray photoelectron spectroscopy(XPS)as well as thermogravimetric analysis(TGA).The photophysical properties,photothermal effect and singlet oxygen generation ability of SWNTs-p-CD-SiPc-F were studied.The SiPc-F was released and fluorescence of SiPc-F was restored by photoinduced process.The SWNTs-p-CD-SiPc-F nanosystem was effective in killing E.coli upon irradiated with 670 nm light.This strategy could be useful for enabling effective and precise photodynamic therapy and photothermal treatment,as well as avoiding the drug resistance during the treatment.