Preparation And Phototherapy Properties Of Near-infrared Phthalocyanine Nanocomposites

Phthalocyanine compounds are excellent photosensitizers because of their good thermal and chemical stability and good absorption in the visible region.In this thesis,we synthesized two kinds of metal-free phthalocyanine dyes which can absorb near-infrared light,which can contain four butylamino groups and can act as photosensitizers,and study their photothermal and reactive oxygen effects on near-infrared light irradiation;Synthesis of a metal organic framework of phthalocyanine and its application in photothermal therapy.?.Nanoparticles HSA-?-Pc and HSA-?-Pc were obtained by self-assembly of?-Pc and?-Pc using human serum albumin?HSA?.The obtained HSA nanoparticles have high absorption in the near-infrared region,low cell dark toxicity and good membrane permeability,and high efficiency of photothermal conversion.HSA-?-Pc showed higher phototoxicity than HSA-?-Pc due to the production of higher reactive oxygen species.The metal-free phthalocyanine-based nanoparticles can be well applied to the treatment of tumor cells by a photosensitizer capable of both photodynamic therapy and photothermal therapy in combination with phototherapy on a single near-infrared source.?.The ZnPc@UiO-68-NH₂ material is obtained by in-situ assembly,and the material has good crystallinity,regular morphology and high photothermal conversion efficiency.The ZnPc@UiO-68-NH₂ material has low cell dark toxicity and high phototoxicity through the property test and cell experiments,and it has obvious advantages in killing tumor cells by photothermal therapy.The results show that:the nanoparticles obtained by self-assembly of the synthesized phthalocyanine molecules have good photodynamic and photothermal properties.The MOFs materials obtained by in-situ assembly have important value in photothermal treatment of tumor cells.