Study On The Chemical Constituents Of Litsea Mollis Hemsl

Litsea mollis Hemsl is a deciduous tree in the genus Litsea.According to "Chinese Materia Medica" and "Chinese Medicine Dictionary",it can be used as a medicinal material for dysmenorrhea,stomach cold and abdominal pain,food stagnation,malaria and phlegm.The fragrant wood ginger has good biological activity,especially anti-inflammatory and anti-oxidant activities,and can be used as a potential source of drug molecules and pharmaceutical raw materials.At present,there are few reports on the chemical constituents of the genus Litsea,especially the systematic study on the chemical constituents of the fragrant wood fragrant ginger.Therefore,the chemical composition of the fragrant wood ginger is systematically studied in this thesis.This thesis consists of two parts.The first part summarized the natural compounds with anti-inflammatory activity reported in the literature since 2010 and classified them according to their structure types.This review laid the foundation for the study of the chemical constituents of the Litsea mollis Hemsl and the subsequent anti-inflammatory activities.The second part details the study of the chemical constituents of the genus Litsea.This part is divided into three chapters on chemical composition research,experiment and result discussion of Litsea mollis Hemsl.In this experiment,a total of 41 compounds were isolated by a variety of chromatographic separation techniques and experimental instruments,and 33 compounds were identified.Among them,13 flavonoids(11-23),3 lucidones(8-10),2 steroids(32,33),and 2 long-chain ferulic acid ester compounds(26-27),4 lignin compounds(1,2,3,25),1 alkaloid compound(4),1 steroid(24),and 7 other types of compounds(4-7,28-31).The compound(-)-9’-O-acetyllyoniresinol(1)is a new natural product and 32 known compounds are 9,9’-O-Di-(E)-feruloyl-(-)-secoisolariciresinol(2),2,6,2’,6’-tetramethoxy-4,4’-bis(2,3-epoxy-1-hydroxypropyl)biphenyl(3),N-traps-feruloyl-3’-methoxytyramine(4),(+)-(R)-de-O-methyllasiodiplodin(5),myricanol(6),schefflerin(7),methyllinderone(8),linderone(9),lucidones(10),4’,5,7-trihydroxy-6,8-dimethylflavanone(11),(-)-epicatechin(12),naringenin(13),quercetin(14),(+)-taxifolin(15),5,7-dihydroxy-6,8-dimethoxyflavone(16),5,6-dihydroxy-7,8-dimethoxy-flavanone(17),5,6-dihydroxy-7-methoxy-flavanone(18),dihydropashanone(19),2’,6’-dihydroxy-4’,5’-dimethoxychalcone(20),2’,6’-dihydroxy-4’-methoxy-dihydrochalcone(21),pinostrobin(22),5-hydroxy-6,7-dimethoxyflavanone(23),chrysophanol(24),(E)-cinnamyl-(E)-cinnamate(25),(Z)-ferulic acid tetracosyl ester(26),(E)-ferulic acid tetracosyl ester(27),bis(2-ethyloctyl)phthalate(28),cinnamic acid(29),3,4-methyl dihydroxybenzoate(30),3,4-dihydroxybenzoic acid(31),3-sitosterol(32),3-daucosterol(33).The compounds 1、2、3、4、5、6、7、8、9、10、11、15、17、18、19、24、25、26、27 and 28 were isolated from Litsea mollis Hemsl for the first time.The compounds 1、3、4、5、6、7、8、9、10、11、15、17、18、19、24、25、26 and 27 were isolated from Litsea for the first time.In addition,we found that a considerable portion of the compounds isolated from the fragrant wood ginger have anti-inflammatory activity.Among them,9,9’-O-Di-(E)-feruloyl-(-)-secoisolariciresinol(2),(-)epicatechin(12),naringenin(13),quercetin(14),(+)Taxifolin(15),chrysophanol(24),these compounds are clearly reported to have significant anti-inflammatory effects,the anti-inflammatory activity of other compounds is currently being tested.