Construction Of Multifunctional Nanodrug Delivery System Based On Gold Nanomaterials And Its Application In Biomedical Field

This thesis mainly includes two parts:review and research work.In the part of review,the definition of nanomaterials,the properties of some functional inorganic nanomaterials represented by gold nanomaterials,and the application of composite nanomaterials based on gold nanomaterials in biomedical field are described.The research work mainly includes two parts:1.Mesoporous silicon-coated gold nanoparticles?Au@MSNs?composite nanomaterials were synthesized based on gold nanoparticles,and a near infrared triggered uPA drug delivery system was prepared.The prepared uPA-Tet@Au@MSNs system is stable at room temperature and has high thermal sensitivity under near infrared laser irradiation,which indicates that the system is a safe and controllable drug delivery system.More importantly,hyperthermia induced by photothermal effect of gold nanoparticles can improve thrombolytic efficiency in vitro and in vivo.This uPA-Tet@Au@MSNs system has good thrombolytic effect and good biocompatibility,which provides new guidance for clinical treatment of thromboembolism patients.2.A new kind of magnetic mesoporous organosilicon-coated gold nanorod?GNRs@MSNs?composite nanomaterials was synthesized based on gold nanorods.Compared with the traditional mesoporous silicon-coated gold nanorods composite nanomaterials,the drug loading is larger,the near infrared heating effect is better,and the magnetic mesoporous organosilicon-coated gold nanorods?Janus GNRs-PMO-Fe₃O₄?composite nanomaterials have the targeting function.Based on this new composite nano-material,a new nano-drug delivery system is constructed by connecting the new composite nano-material with the external 3D printing Wearable device,which can precisely target the tumors and achieve a more precise combination of chemotherapy and hyperthermia for cancer treatment.