Studies On The Formation Of Thiophosphate And N-Alkylaminopyridine In The Presence Of Peroxide

Peroxide is a very common reagent and it is also a widely used oxidant and free radical initiator in organic reactions.Therefore,from the perspective of the role of peroxides in organic synthesis,the paper promotes the synthesis of thiophosphate esters and N-alkylaminopyridine through the role of peroxides.In the first part,The dehydrogenation coupling reaction of hydrogen peroxide with hydrocarbyl thiosulfate(bunte salt)and phosphite was studied.In this reaction,bunte salt was oxidized by hydrogen peroxide to form dialkyl disulfide.Under the action of hydrogen peroxide,halogen ion reacts with dithioether to form bromide ion cycle,and reacts with phosphite ester to form thiophosphate in the cycle.The reaction system takes hydrocarbyl thiosulfate as the sulfur source and has the advantages of non-metal catalysis,mild reaction conditions and short reaction time.It provides a new route for the synthesis of thiophosphate.In the second part,the free radical reaction of ditert-butyl hydrogen peroxide with aminopyridine and toluene is studied.In this reaction,N-alkylaminopyridine compounds were obtained by coupling the C-N bond of the aminopyridine compounds with toluene using the ditert-butyl hydrogen peroxide as a free radical initiator.On this basis,we also extended the reaction of cyclohexane with aminopyridine,with a moderate yield.This reaction provides a new method for the synthesis of secondary amines.