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Applications Of Calcium Carbonate On Drugs Loading And Release

Posted on:2019-02-25Degree:MasterType:Thesis
Country:ChinaCandidate:D W WuFull Text:PDF
GTID:2381330596482318Subject:Materials Science and Engineering
Abstract/Summary:PDF Full Text Request
Drug loading and sustained release are the continuing research hotspots in the field of biopharmaceuticals.Drugs delivery system is an effective way to reduce toxic and side effects in cancer chemotherapy.The calcium carbonate microspheres are easy to be prepared,with good biocompatibility and large specific surface area,and they are promising inorganic carrier.Hydrophilic drug doxorubicin and hydrophobic drug curcumin are used as model drugs to study the drug-loading propertie of the calcium carbonate microspheres and drug release behavior.Calcium carbonate microspheres were prepared by coprecipitation method and templates strategy,respectively.To get uniform sphere shape vaterite calcium carbonate microspheres,polyvinylpyrrolidone(PVP),absolute ethanol and soybean protein were used as stablier.And hollow structure calcium carbonate microspheres were obtained by templates strategy.Anhydrous calcium chloride and sodium carbonate are used as raw materials,and sodium dodecyl sulfate(SDS)and Tetraethoxysilane(TEOS)are used as templating agents.The morphology of the carrier was observed by scanning electron microscopy.The surface chemical structure of the modified surface was analyzed by infrared spectroscopy.The drug loading rate and encapsulation efficiency were calculated by UV spectrophotometer.The in vitro release performance of the drug was studied by dialysis bag method.The results showed that compared with absolute ethanol and polypyrrolidone,soy protein isolate is more conducive to the formation of vaterite calcium carbonate,and to the reduce of agglomeration.As a result,the prepared calcium carbonate crystals are spherical and uniform in particle size;During the preparation process of template method,carriers prepared with SDS as a template have a higher drug loading rate than that of TEOS,which may be related to longer SDS chain length.After the calcium carbonate carrier is modified with a silane coupling agent,the drug loading rate of curcumin is significantly increased for the hydrophobic drug,which is due to the interaction between the coupling agent and the hydrophobic drug after the surface of the calcium carbonate is bonded to the silane coupling agent,leading to significantly increased drug loading.The in vitro sustained release test of the drug showed that both drugs exhibited a certain sustained release property in PBS of pH=7.4,especially the hollow structure calcium carbonate carrier was superior in performance.At the same time,the calcium carbonate carrier exhibits significant pH sensitivity.
Keywords/Search Tags:calcium carbonate microspheres, drug carriers, sustained-release properties, pH sensitivity
PDF Full Text Request
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