Studies On The Palladium Catalysed Annulation Reaction Of Vinylcyclopropanes With Pentafulvenes

Donor-Acceptor(D-A)cyclopropane is a widely used organic synthetic block,especially in the construction of cyclic compound.This thesis primarily study on the palladium catalyzed annulation reaction for vinylcyclopropanes(VCPs)with fulvenes and lewis acid catalyzed ring-opening reaction for D-A cyclopropanes(DACs)with α-angelica lactones.The main research contents and results are as following three parts:Chapter 1: The research advance of DACs and VCPs in recent five years was reviewed.Especially,we introduced the lewis acid and palladium catalyzed annulations,ring-opening reactions,the reaction mechanisms and good application prospect in building nature products and drug molecule frameworks.Chapter 2: A simple overview about the annulations with pentafulvenes served as 2π and 6π cycloaddition partner.On this basis,the palladium catalyzed [3+2]-annulation reaction for VCPs with pentafulvenes was designed and carried out.And an effective method for the synthesis of spiro[4,4]nona-6,8-dienes derivatives had be developed.Diels-Alder reaction and RCM reaction were used for further derivatization and application in the construction of polycyclic compounds.Chapter 3: We design and developed the lewis acid catalyzed ring-opening reaction for DACs with α-angelica lactones,base on the review about the lewis acid catalyzed Michael-type and Mannich reaction of α-angelica lactones recently.