Optical Properties Of Ion-doped Fluoroapatite Upconversion Materials

Up-conversion nanomaterials have potential value in biomedical applications due to their excellent optical properties and low toxicity.With the continuous development of biomedicine,the development and optimization of bio-nanofluorescent probes with strong optical properties and low biological toxicity has become a hot research topic.Therefore,rare earth doped up-conversion nanoluminescent materials have become a hot material for researchers.Fluoroapatite(FA:Yb³⁺Ho³⁺)nanomaterials were successfully prepared by hydrothermal method.Then,the optical properties of FA:Yb³⁺Ho³⁺nanomaterials doped with different ions and different concentrations were characterized by fluorescence spectrometer.The influencing factors of optical properties were studied.Finally,the hydrophilicity of the materials was realized by wrapping fluoroapatite with dextran.The contents are as follows:?1?In this paper,rod-like FA:Yb³⁺Ho³⁺nanomaterials with uniform size were successfully prepared by hydrothermal method,and the phase characterization and fluorescence properties of the samples were studied.?2?The FA:Yb³⁺Ho³⁺was doped with ions.Firstly,the concentration of doped ions was changed by using the same elements.It was observed that the fluorescence intensity increased gradually with the increase of doping concentration,and decreased with the increase of doping concentration after reaching the peak value.Then,the doped ions are doped by changing the doping concentration with the same ion doping concentration.When the doping concentration is 3%,Ba²⁺?Sr²⁺?Na⁺?Mg²⁺ions are doped respectively.The results show that the relative fluorescence intensity of doped Na⁺ions is the strongest.?3?Hydrophobic FA:Yb³⁺Ho³⁺nanomaterials were coated with dextran and applied to macrophage detection.The results showed that the cell survival rate of FA:Yb³⁺Ho³⁺Na⁺was higher than 70%even at higher concentration.This low toxicity and up-conversion luminescence FA:Yb³⁺Ho³⁺nano-material is expected to be further applied in biomedicine due to its excellent fluorescence imaging effect.