Metal(Ni,Co,Cu)based Metal-organic Framework Electrode For Glucose Sensing

Diabetes mellitus is a metabolic disease with high incidence that threatens human health.It is also one of the important causes of complications such as ketoacidosis,eye diseases,and high-acid coma as well as lower limb amputation.Data show that the number of diabetes patients increased from 108 million in 1980 to more than 400 million in 2019,the number is expected to continue to rise in the future.At present,diabetes is tested by regularly measuring a patient's blood sugar to know the body's metabolism timely,in order to achieve normal of glucose content.Hence,fast,simple and convenient methods to glucose detection has attracted more and more attention for researchers.A variety of methods have been used for glucose sensor.Based on the distinct merits of electrochemical techniques in the field of analysis,it is vital to explore the fast and convenient glucose detection.However,poor stability,low sensitivity and weak environmental suitability restrain vastly electroanalytical technique large-scale application.Much attention has therefore been focused on designing and developing novel nanomaterials to improve the existing issue.Transition metal-based MOF materials display splendid advantages in electrical conductivity and other aspects.We focus our curiosity on the materials of Ni-MOF/NF,Co-MOF/NF and Cu-MOF/CF.The materials were successfully synthesized and served as glucose sensor.The sensor not only provides a novel strategy for detecting glucose,but improves the sensitivity and detection range.The primary contents are as follows:1?Ni-MOF/NF was prepared by hydrothermal reaction as sensor for determination of glucose.The Ni-MOF was characterized by SEM,XPS and TEM.The electrochemical response of Ni-MOF/NF electrode to glucose was researched by consecutive condition optimization.Under optimal experimental conditions,the detection limit of glucose is as low as 85 nM?S/N=3?with a high sensitivity of 14845?A mM^-1cm^-2 and broad linear range of0.04² mM.Ni-MOF/NF is also applied to detect actual human serum.As an electrochemical sensor with simple,inexpensive and low detection limit,Ni-MOF/NF materials is potential candidate for small molecules detection in the sensing field.2?Co-MOF/NF were synthesized by ambient temperature reaction as glucose sensor.The element composition,structure and surface morphology of Co-MOF/NF were characterized by all kinds of analytical methods.The electrocatalysis of nanomaterials on glucose exhibits remarkable performance?S/N=3?,including linear range?0.0025¹.3 mM?,the detection limit?13.9 nM?and sensitivity(165.25 mA M^-1cm^-2).In addition,Co-MOF/NF also shows good reproducibility and stability.Furthermore,Co-MOF/NF displays hardly response to interference molecules which demonstrates excellent selectivity.3?Cu-MOF/CF nanorod was prepared by in-situ conversion of CF?Cu foam?.The outstanding electrode structure allows Cu-MOF/CF to product a larger effective surface area and helps molecules attack from 360?.The electrocatalytic performance of Cu-MOF/CF nanorod on glucose sensor was detected by LSV,it and so on.Data confirms that Cu-MOF/CF nanorod displays excellent response to glucose.The minimum limit of detection even as low as 10 nM?S/N=3?,a high sensitivity of 26987?A mM^-1 cm^-2.Moreover,it possesses high selectivity,stability;fresh serum analysis is also successfully accepted.