Surface Modification Of Ultrasound Imaging Medical Catheter Material

An ultrasound interventional catheter is an interventional catheter that is imaged by an ultrasound imaging device.When the catheter enters the body,the catheter is in contact with the internal tissues of the human body.The surface of the catheter material needs to have hydrophilicity,anti-protein adsorption and lubricity.Most of the materials of interventional catheter do not have the above surface properties before they are modified.A common method of surface modification of a catheter is a physical coating method,but this method has a risk of shedding.In order to avoid this problem from the design,we take the biaxially oriented polypropylene film(BOPP)as the research model,and use the chemical method(ultraviolet light grafting method)to modify the surface of the polypropylene intervening catheter material.The effects of different modification methods and grafting monomers on hydrophilicity,anti-protein adsorption and lubricity were investigated.The main contents are as follows:1.Polyethylene glycol monomethyl ether methacrylate(PEGMA)are grafted onto the surface of BOPP film by ultraviolet light.The hydrophilicity,lubricity and anti-protein adhesion ability of the film were enhanced.When the graft ratio of PEGMA was 47.9%,the contact angle of BOPP film decreased from 105.6±0.4° to 22.9±3.2°,and the friction coefficient decreased from 0.39 to 0.11.Fluorescent labeling protein adsorption experiments showed that the number of protein adsorbed on the surface of the modified polypropylene significantly reduced.2.The copolymer of N-vinylformamide(NVF)and polyethylene glycol monomethyl ether methacrylate(PEGMA)are grafted onto the surface of BOPP film by ultraviolet light.The hydrophilicity,lubricity and anti-protein adhesion ability of the film were enhanced.When the feed ratio of NVF and PEGMA was 6/8 and the graft ratio of the copolymer was 45.7%,the contact angle of BOPP film decreased from 105.6±0.4° to 22.3±2.4°,and the friction coefficient decreased from 0.39 to 0.08.Fluorescent labeling protein adsorption experiments showed that the number of protein adsorbed on the surface of the modified polypropylene significantly reduced.Compared with UV-grafted PEGMA,the BOPP film surface grafted with the copolymer has smaller roughness and friction coefficient.3.The surface of the BOPP film is modified by ultraviolet light grafting to introduce a reactive functional group on the surface of the material.The PEGMA solution containing the initiator and the crosslinking agent is coated on the surface of the BOPP film,then a hydrophilic lubricating hydrogel layer was obtained on the surface of the polypropylene after the reaction.The contact angle of BOPP film decreased from 105.6±0.4° to 22.4± 1.1°,and the friction coefficient decreased from 0.39 to 0.05.Fluorescent labeling protein adsorption experiments showed that the number of protein adsorbed on the surface of the modified polypropylene significantly reduced.