New Antifungal Polymer Based On Menthol

Fungal pollution has led to the huge economic losses in agriculture and industry,and also causes risks of disease.Till now,there are still few methods to control fungal contamination.Therefore,developing new material especially with antifungal adhesion and transmission properties is thus highly desired.Traditional antifungal materials mainly kill fungal or inhibit fungal growth,which were generally modified with an antifungal agent through combining antifungal agents to materials during the synthesis,endowing antifungal properties of the whole material.However,a serious toxicity is posed to traditional antifungal materials.On the one hand,it is harmful to human health.On the other hand,long-term use may lead to the emergence of resistant fungal.Menthol is a natural plant-derived terpenoid compound with three chiral centers,belonging to the terpenol ring,which has been used in the biological field for more than 100 years.Herein,the compound 2,4-dichloro-6-menthyl-1,3,5-triazine(DMT)was synthesized by the substitution reaction of menthol with cyanuric chloride(TCT).Subsequently,a new antifungal polymer P(MT-alt-ODA)containing menthoxy group was prepared by condensation polymerization of nucleophilic reagent 4,4'-oxydianiline with DMT as an intermediate.To emphasize the antifungal performance of the menthoxy group,a series of similar polymers derived correspondingly with hydrogen,ethoxy and decoxy groups were prepared and served as controls.The structure of the polymers were characterized by various methods such as 1H NMR,FTIR,GPC and TGA.Aspergillus niger was selected as the test strain,and the antifungal superior antifungal efficacy of the material was verified with"disembark" and "anti-spore germination" models.Comparing hydrophobicity with control group and inhibition zones test proved that the stereochemical structure of the material is the main mechanism of interface antifungal properties.The main contents and results are as follows:1.Antifungal polymer P(MT-alt-ODA)and its control groups named as P(ET-alt-ODA),P(ST-alt-ODA)and P(T-alt-ODA)were synthesized respectively.2.1H NMR,FTIR,GPC and TGA and otheranalytical techniques were employed to prove the structural of the polymers.3.P(MT-alt-ODA)can slow the growth rate of the fungal hyphae and inhibit the production of Aspergillus niger spores via the "disembark"model.4.P(MT-alt-ODA)can inhibit the diffusion and growth of Aspergillus niger spores with the "anti-spore germination" model.5.CA test and the inhibition zone of the bacteria demonstrated that the stereochemical structure of P(MT-alt-ODA)is the main mechanism of antifungal properties.