Visible Light Catalyzed Asymmetric Free Radical Conjugate Addition Reaction Of N-arylglycine And Azaaromatic Hydrocarbon Activated Olefins

Azarenes are essential structural motifs found in an array of pharmaceuticals,agrochemicals and natural products.This explains why synthetic methods that facilitate the construction of structurally complex pyridine-containing molecules are highly sought after.Although the direct functionalisation of the heterocyclic ring continues to be the main approach,synthetic strategies that feature functionalisation at a remote position have also garnered attention.In particular,alkenylpyridines have long been known as good Michael acceptors.The synthesis of functionalized azarenes through the additive reaction of alkenylpyridines will also be a synthetic strategy with theimportant theory significance and the strong application value.Based on the advantages of photoredox reaction and the research interest of our group in H-bonding organocatalysis,visible light-driven photoredox catalysis and cooperative photoredox and asymmetric catalysis on asymmetric hydrogen bonding organic catalysis.We adopt self-development dicyanopyrazine derivatives DPZ as a photosensitizer and Br?nsted acid as a chiral catalyst to complete the study of the free radicals asymmetric conjugate addition between N-arylglycine and alkenylpyridines.