Study On Antimicrobial Performance Of UV-Induced Graft Borneol-PEG Material

Preventing harmful microorganisms from polluting the surface of materials has always been a research hotspot in the fields of biomedicine,food storage and textiles.Some microorganisms(such as bacteria,fungi,etc.)adhere to the surface of biomaterials and form biofilms,causing related infections and even death,which seriously threatens people's health.Many methods have been developed to prevent microbial adhesion,including anti-adhesion coatings and release coatings.However,these methods are usually limited by their durability,stability,safety,and resistance to antibiotics,and satisfactory results cannot be obtained.Therefore,it is necessary to design a safe,efficient and stable antimicrobial coating.The objective of this study is to modify the surface of the material with antimicrobial coating by photografting.Introduce benzophenone(BP)and isopropyl thioxanthone(ITX),which can generate surface active radicals,and introduce borneol and polyethylene glycol molecules on the surface of the material.Synthesizing amphiphilic and stereochemical antibacterial strategies to achieve the modification of non-release antibacterial coating grafted on substrateFirst,the process of photo-grafting was explored,and the grafting of borneol acrylate with polyethylene(PE)film as the substrate proved the success of grafting.And optimize the process according to the existing problems,improve the grafting efficiency and surface smoothness.Polyethylene glycol diacrylate(PEGDA)was added as a hydrophilic segment to realize the grafting of PE film and increase the grafting efficiency.The co-culture experiment of Staphylococcus aureus and Pseudomonas aeruginosa proved that the addition of PEGDA has an enhanced antibacterial adhesion effect.Finally,polyacrylonitrile,which is susceptible to fungal contamination,was selected as the substrate for grafting,and coatings with different proportions of BA and PEGDA were synthesized.Through landing experiments on Aspergillus niger,it was proved that the ratio of BA and PEGDA showed anti-adhesion regularity.When the ratio of BA and PEGDA was 1:1,the anti-fungal adhesion reached the best effect.