Study On The Action Behavior Of Ibuprofen Nickel Titanium Bimetallic Hydroxide

Layered Double Hydroxides(LDHs)is a layered material with a well-known name of hydrotalcite.LDHs are a class of columnar compounds composed of a positively charged metal hydroxide layer and an interlayer filled exchangeable anion.Due to the hydrogen bond,electrostatic attraction and steric hindrance effect between the group or the ion and the layer,effective release of the drug can be achieved.Therefore,LDHs can be used as an excellent drug carrier to synthesize the drug@LDHs hybrid,becoming a kind of promising drug delivery-sustained release system.However,since the current research on the hybrid mechanism of double metal hydroxides and organic drug molecules is not mature,there are still many key scientific problems that require further efforts.1.Using Ibuprofen(IBU)as the model guest and Ni-Ti-LDHs as the carrier,IBU-LDHs hybrid was prepared by changing the composite molar ratio of IBU and LDHs,which was further characterized by XRD,TG,DTG and FT-IR to explore its hybrid mechanism.FT-IR spectrum indicated that the LDHs after intercalation showed characteristic peaks of benzene ring and alkyl group,and the characteristic peak of NO3-disappeared or weakened.The TG curve showed that the weight loss of NO3-and OH-were significantly reduced and the weight loss temperature of phenanthrene anion increased.Therefore,it is speculated that the hybridization mechanism is that the interlayer anion NO3-exchanges with the ibuprofen anion,and the hydroxyl group interacts with the anion.These findings provide theoretical support for the study of hybridization of drug molecules and LDHs.2.Layered Nickel-titanium double hydroxide was prepared by coprecipitation method,and the nanosheets were obtained by liquid phase stripping method.Based on the combination of ibuprofen and the above as-prepared LDHs materials,the corresponding ibuprofen@Ni-Ti LDHs complex and ibuprofen@Ni-Ti-LDHs nanosheet nanocomposite were obtained.The crystal phase structure of the sample was characterized by XRD.The functional group and the structure of the sample were analyzed by FT-IR spectroscopy.The morphology of the sample was observed by SEM.The change of the absorbance of the buffer solution containing ibuprofen was measured by UV-Vis sprectrum.The intercalation-deintercalation behavior of ibuprofen in the LDHs layer and the adsorption-desorption behavior on the surface of the nanosheets were investigated.The results show that the crystallinity changes after being stripped into nanosheets,which is inferior to the original sample,but the layered structure can still be observed.The experimental results further indicate that the interaction between-COOH of ibuprofen and Ti-OH of LDHs is responsible for successful intercalation and loading.The release experiments showed that the release time of ibuprofen adsorbed on the nanosheets was longer than that of the LDHs layer,and it had a certain sustained release effect The fitting results of the kinetic equations showed that the desorption and desorption behavior on the surface of the nanosheet conforms to the pseudo second-order kinetic equation.