Piezoelectric And Photothermal Dual Functional Film For Enhanced Dermalwound Regeneration Via Upregulation Of Hsp90 And HIF-1?

Skin wounds,especially chronic wounds such as pressure and diabetic ulcers,are posing a huge threat to healthcare systems worldwide.Thus,novel strategies to realize effective wound therapy are nowadays extremely needed.Herein,we are the first to report a combination therapy of electric stimulation and heat for wound healing just using a facile piezoelectric and photothermal dual functional film.The film is simply fabricated by coating polydopamine on a chitosan film.The film(CM@DA,Polydopamine Coated Chitosan Films)generates electric voltages under mechanical pressure and shows photothermal effect with irradiation of near-infra red(NIR)light.In vivo experiment with rat full-thickness wound model validates that CM@DA with NIR can effectively promote wound regeneration due to the generation of electric stimulation and heat on wounds.The healing mechanism of CM@DA is further investigated,and the result demonstrates that CM@DA enhances wound healing through a pathway in which heat shock protein 90(Hsp90)and hypoxia-inducible factor 1?(HIF-1?)participate.These results indicate that CM@DA is a promising wound dressing candidate for clinical application in the future.