Preparation,Property Modulation,and Application Research Of Multi-functional Bi/Bi₂S₃-based Nanomaterials

In recent years,the inorganic theranostic nanoprobe has been extensively studied,which provides an important platform for improving the accurate diagnosis and efficient treatment of tumors,and also provides the possibility to overcome the shortcomings of traditional treatment and diagnostic methods.Bismuth?Bi?-based nanomaterials are widely researched in the diagnosis and treatment of cancer due to their unique physical and chemical properties,such as it has extremely high X-ray attenuation coefficient,good photoacoustic?PA?imaging function,excellent photothermal/photoelectric/photocatalytic characteristics,low cost and simple preparation process.However,the application research of Bi-based nanomaterials in the diagnosis and treatment of cancer is still in the preliminary stage,and many aspects need to be further studied.For example,the structure and functional characteristics need to be improved and optimized,the biosafety assessment needs to be further improved,and the integrated mechanism of multimodal diagnosis and treatment can be more widely developed and optimized.At present,it has become a hot research direction to construct an efficient multi-mode collaborative therapy and diagnosis platform for tumors based on photothermal nanomaterials.Therefore,this paper is aim to explore novel and multi-functional Bi/Bi₂S₃-based nanomaterials to construct the new multimodal synergistic diagnosis and therapy platform and to realize its performance regulation and biomedical application research.The specific contents are as follows:?1?Template method and polydopamine?PDA?coating method were developed and the hollow Bi₂S₃ nanocomposite coated with PDA?H-Bi₂S₃@PDA?was constructed successfully.The photothermal property,and photothermal/PA/X-ray imaging performance of this nanocomposites were researched.The results show that the H-Bi₂S₃@PDA nanocomposites have ideal photothermal conversion efficiency??46.18%?and the diagnostic potential of multimodal?photothermal/PA/X-ray imaging?imaging.The successful synthesis of this material provides a new research basis for the study of multimodal image-guided bismuth sulfide based inorganic photothermal therapy system.?2?Further binding to the thermal-sensitive molecules?S-nitrosothiols,RSNO?of the NO gas-releasing,the near-infrared?NIR?light photothermal-triggered NO gas generator was successful constructed.The result of research shows that this generator possesses good biocompatibility,stability of biological temperature?37??,and NO gas release characteristic controlled by NIR light.Furthermore,in vivo photothermal/NO gas synergistic treatment of tumor was further realized,showing excellent synergistic anti-tumor effect.This provides an idea for the construction of NIR-responsive photothermal/NO gas multi-mode treatment nanoplatform.?3?The sacrificial template method was developed to construct the hollow mesoporous Bi nanoshell?HM-Bi@PEG-FA?as a p H/NIR light dual-stimuli-responsive of single"element"photothermal nanocarrier.The result of research shows that the nanocarrier holds the excellent photothermal conversion efficiency??34.72%?.And it has a big specific surface area(?76.28 m²·g^-1)and mesoporous aperture??3.33 nm?,which make it possesses high capacity of drug loading??78%?and dual-stimulating?acidic pH/NIR laser?controllable drug release.More important,HM-Bi@PEG-FA showed a high level of biosecurity and high efficiency of synergistic chemo-photothermal therapy in vivo and in vitro experiments.This work lays a foundation for the exploration of novel stimulus-responsive bismuth-based photothermal nanocarriers for the efficient and synergistic chemotherapy/photothermal treatment of tumors.