Study On Construction And Design Of Two Supermolecular Functional Materials Of Nanomicelles And Self-Healing Hydrogels

With the development of science and technology in recent years,the demand for nanomicelles and self-healing hydrogel functional materials is increasing.Self-healing hydrogels and nanomicelles have many unique advantages as drug carriers,and they all show good application prospects in the field of new drug delivery systems.Self-healing materials are also widely used in batteries and coatings.This thesis mainly studies materials from two aspects: nanomicelles and self-healing hydrogels.1.Study on preparation of nanomicelles based on pluronicWe constructed a series of Pluronic nanoaggregate micelles and explored the structural characteristics and physical and chemical properties of different types of pluronic micelles.First,nano-micelles are prepared,and a hydrophobic complex formed by the electrostatic interaction between DOX and sodium deoxycholate is encapsulated in the nano-micelles to obtain a pluronic drug-loaded micelle.The corresponding critical micelle concentration,particle size and Zeta potential of drug-loaded micelles and blank micelles,the content of doxorubicin in micelles,and the cumulative release behavior of drug-loaded micelles at different temperatures and pH were measured.Experiments show that the drug loading of the prepared Pluronic F127,F128 and F68 micelles are(0.15±0.1)%,(0.16±0.07)% and(0.17±0.1)%,respectively,and the encapsulation rate is(3.03±0.24)%,(3.11±0.147)% and(3.36±0.024)%.The study found that pluronic nano-aggregate micelles have certain environmental responsiveness and have potential application value in the field of drug loading.2.Construction of self-healing hydrogel based on UPy quaternary hydrogen bondWe generated a UPy moiety with a quaternary hydrogen bond through the reaction between isocyanate and 2-amino-4-hydroxy-6-methylpyrimidine(AHMP),and then the UPy moiety with a quaternary hydrogen bond and acrylic acid-2-Methoxyethyl ester monomer copolymerization.By adjusting the ratio of the polymer matrix and the hydrogen bonding portion,in this way,elastomers with different strengths,toughnesses,and self-healing abilities are obtained.The thesis mainly examines the swelling properties,water retention properties,mechanical properties and self-healing properties of hydrogels.With the increase of the specific gravity of hydrogen bonds in the hydrogel,the breaking strength changes rapidly up to 3.31 MPa.At the same time,the elongation at break can be up to 1200%.The material self-heals at room temperature for 24 hours,and the healing efficiency reaches about 40%,which provides a theoretical reference for the construction and design of functional materials.