Studies On The Drug Loading Behaviors Of The Oxygen Nanocomposites Of Copper And Cobalt And Their Electrocatalysis Study

In recent years,the incidence and mortality of cancer in China has continued to rise and cancer has become one of the leading causes of death.In cancer treatment,most anticancer drugs have the danger of killing other normal tissue cells.In order to reduce the toxic and side effects of the drug and exert the maximum effect of the drug itself,special carriers are required to solve this problem.At present,many researches are focused on the use of single atom and heterogeneous nanomaterials?high drug loading rate,controllable particle size and sustained release?loaded with anticancer drugs to prevent the spread of cancer cells and achieve the goal of targeted treatment.Catalyst Fe₃O₄ can effectively induce tumor specific in situ Fenton reaction in acid environment?cancer cells?,which leads to cancer cell apoptosis.In the absence of external stimulation or hypoxia,Oxygen evolution reaction?OER?can catalyze biochemical reactions in cells to produce highly active singlet oxygen or reactive oxygen species?ROS?,which can inhibit or kill tumor cells.Simultaneously,OER can produce clean and green energy to reduce the consumption of fossil energy.Therefore,pharmaceutical nanomaterials and catalysis are quietly linked..In recent years,inorganic non-metallic nanomaterials have attracted widespread attention.In this study,cuprous oxide cubic microcrystals were used as templates to prepare compounds composite materials that hollow porous CuO cubic loaded flake cobalt by introducing magnetic element cobalt under room temperature stirring.The release properties,drug loading and biocompatibility of anticancer drugs loaded with cubic cobalt compounds at different pH values were investigated.At the same time,a small amount of sulfur was introduced into the cobalt compound to prepare excellent electrocatalyst.The main research contents are as follows1.The magnetic CuO@CoO-x?where x is the molar ratio of cuprous oxide and cobalt chloride?composite material was obtained at room temperature by in-situ self-assembly on the surface of Cu₂O cube with cuprous oxide cubic crystallite as template,cobalt chloride aqueous solution as cobalt source and sodium hydroxide as inducer,respectively.Among them,Energy dispersive X-ray spectroscopy?EDX?analysis,X-ray diffraction?XRD?,scanning electron microscope?SEM?,and transmission electron microscope?TEM?were used to characterize the composite materials.When x is 0.2,the composite materials contain a large number of mesoporous,which are conducive to solution wetting and high drug loading and have potential as drug carriers and electrocatalyst.2.5-Fluorouracil was loaded into the prepared CuO@CoO complex by solvent evaporation method.The loading of 5-Fu-loaded CuO@CoO complex was confirmed by XRD,TEM,and SEM.Based on the analysis of the characterization spectrum,5-fluorouracil has been successfully loaded in the material.The adsorption and release properties of5-fluorouracil in different pH solutions were studied.When loaded on CuO@Co O-2,the drug loading can reach 48.87%.In the medium with pH=7.4,CuO@Co O loading not only prolongs the dissolution time,but also increases the dissolution,achieves the effect of slow release and has pH dependence,which is far better than the simple 5-fluorouracil.Then we evaluated the stability and anti-inflammatory effect of the drug.The hemolysis experiment of the material was studied subsequently.The results showed that when the concentration was in the range of 25-100?g/ml,the toxicity of the carrier material to red blood cells was less,so it had better biocompatibility.In addition,the cytotoxicity of raw 264.7cells was investigated.The results showed that raw 264.7 cells had no significant toxicity when the concentration was less than 25?M.3.Using cuprous oxide crystallites as a template,sulfur and cobalt elements were introduced on the surface by in situ exchange and chemical deposition methods to prepare flower-like nanocomposite.The catalytic performance of oxygen evolution reaction?OER?in alkaline condition was investigated.It was characterized by SEM,TEM,XRD and XPS,respectively.It was shown that the obtained sample is similar to a seven-color flower-like composite material and composed of Cu₂S and CoO.In the electrochemical test,Cu₂S@Co O-2 can be used as a high activity OER electrocatalyst.The over potential at the current density of10 mA cm^-2 in 0.1 M KOH solution is only 0.280 V and the corresponding Tafel slope value is only 88 mV dec^-1,which is significantly lower than commercial RuO₂ catalyst.Meanwhile,Cu₂S@CoO^-2 catalyst has high stability.