Synthesis Of Tetra-substituted Olefin And Benzoin By Electrochemical Oxidation

Electrochemical catalytic synthesis of organic molecules has attracted much attention in recent years.Due to its inherent characteristics of sustainability and environmental friendliness,direct functionalization of C-H bonds or simple substrates by electrochemical oxidation has become a hot topic.There have been many relevant reports in this field.It is a simple and convenient way to obtain the target molecule through simple activation of C(sp3)-H bond of acetonitrile and introduction of cyanogroup and direct oxidation of alkynes.This paper mainly includes the following two parts of the research:(1)The first part develops a simple and efficient reaction of acetonitrile C(sp3)-H bond activation in the absence of transition metals and the direct conversion of thiophenols to cyanogen-containing tetra-substituted alkenes.In this reaction,a variety of cyanotetra-substituted alkenes containing cyanotetra-substituted alkenes,which are widely existed in natural products and drug molecules,were synthesized,and the experiments in gram scale were successfully carried out.(2)In the second part,a direct electrochemical synthesis of benzoin ether from alkynes was developed.This transformation can be carried out under mild reaction conditions without the need for external oxidants and transition metal catalysts.Preliminary mechanism studies indicate that the product carbonyl oxygen is derived from water.