Preparation Of Platinum Graphitic Nanocapsules And Its Application In Cancer Theranostic

Cancer is a continuing crisis for global public health because of its high mortality and rapid invasiveness.So it is urgent to research into cancer treatment methods.At present,radiotherapy and chemotherapy are the two commonly used cancer treatment methods in clinic,which often cause damage to healthy tissues,fail to achieve complete cancer eradication.As a new cancer treatment method,photothermal therapy Which uses high temperature to destroy or kill cancer cells by raising the local temperature of the tumor.Moreover,studies have found that photothermal-induced elevated body temperature may be beneficial for the body to recover from certain diseases,because when the body temperature rises,the pathogen may slow down the growth,and the enzymes in the virus may be inactivated.Therefore,photothermal therapy has become one of the most promising cancer treatment methods.With the advancement of research on the application of nanomaterials in cancer therapy,nanomaterials,as a thermotherapy agent,can not only rapidly heat up,kill cancer cells.and eliminate tumors,but also can be specifically enriched in the tumor by targeted modification.The tumor rapidly heats up locally during hyperthermia to reduce damage to surrounding normal tissue.However,single-function hyperthermia has failed to meet the requirements of current cancer nanomedicine,so it is urgent to develop a multifunctional nanomaterial that can integrate image and treatment.In this paper,platinum-based graphene nanocapsules?CoPt@G and Pt@G?were synthesized by chemical vapor deposition,and their physicochemical properties were characterized by a series of functions,the surface of CoPt@G and Pt@G are functionalized to explore their application in cancer diagnosis and treatment.The main contents are as follows:?1?The CoPt@G graphene nanocapsules were synthesized and characterized by various analytical methods.An organic iodine molecule was synthesized with1-Pyrene methanol and triiodobenzoic acid.Then it was modified on the surface of CoPt@G graphene nanocapsules?CoPt@G-TPE?by strong?-?stacking interaction with graphene,and CT imaging was performed.?2?In this chapter Pt@G graphene nanocapsules were synthesized.After examining the physicochemical properties,the tumor-targeting molecular folate complex(C₁₈-PEG-FA)was modified to the surface of the particles,Due to the Raman characteristic peak of graphene,we performed targeted Raman imaging on different cancer cells.At the same time,the CT imaging effect of Pt@G was also examined.?3?We explored the heating effect of Pt@G,and then investigated the thermal stability of Pt@G-FA and the effect of cancer cell hyperthermia.