Contributions And Molecular Mechanisms Of PM_2.5 Bounded Pahs In Coking Areas To The Development Of Lung Cancer

As a key area for air pollution control,the Fenwei Plain area was first mentioned as the "main battlefield" of the Blue Sky Defense War.Its energy structure is still dominated by coal.After the transformation and upgrading of the coking industry in Shanxi Province as a pillar industry,PM_2.5 pollution in coking clusters has been significantly improved.However,PM_2.5-loaded PAHs still have potential carcinogenic risks that cannot be ignored.At present,people have a preliminary understanding of the PM_2.5-PAHs emission characteristics and carcinogenic health risks of coking accumulation areas.However,the molecular mechanism and origin of PM_2.5-PAHs in different stages of lung cancer development and development Its contribution is unclear.In this study,we analyzed the PM_2.5 and PM_2.5-PAH emission concentrations in the coking accumulation area,studied the pollution characteristics of PAHs with seasonal changes,analyzed the distribution and source of PAHs ring numbers,and further explored the different ring numbers,The oncological effects of PAHs from different sources on the immune escape-invasion-metastasis-hematologic adhesion of lung cancer and their mechanisms and contributions.Our results show that the atmospheric PM_2.5 concentration in the Yi'an Industrial Park,Jiexiu City,Shanxi Province ranges from 35.46 to 271.21 ?g/m³,with an average concentration of 111.11 ?g/m³.The average daily concentration of 17 PAHs varies from 33.03 to 4319.10 ng/m³,with an average concentration of 694.30 ng/m³.At this sampling point,the atmospheric PM_2.5 and PM_2.5-PAHs concentrations are much higher than those of other industrial cities in northern China.We found that 7 typical PAHs: Icd P,B [a] P,Dba,Chr,B [b] F,B [k] F,B [a] A carcinogens contribute the most to the total carcinogenic risk,of which 5 ring PAHs have The human carcinogenic risk is greatest by inhalation exposure,and the carcinogenic risk to adults and children is much higher than the acceptable risk.We also found that PAHs with different structural characteristics contribute differently to the biological process of lung cancer tumors.The correlation between the tricyclic and tetracyclic PAHs attached to PM_2.5 in autumn and winter and the expression of the marker factor PD-L1 during the immune escape of tumor cells Higher,PM_2.5 attached bicyclic and tricyclic PAHs can significantly increase the ability of lung cancer tumor cells to invade and metastasize.The correlation between PM_2.5 attached pentacyclic PAHs in summer and autumn and the tumorigenic effect of vascular endothelial cells on tumor cells The highest contribution rate analysis shows that PAHs from coking sources and PAHs from traffic sources have a greater contribution to tumor immune escape,and PAHs from coking sources have a stronger ability to induce tumor cell invasion and metastasis and can induce hematologic adhesion of tumor cells.This study studied the PM_2.5 emission characteristics of coking industrial plants in Shanxi Province and their induced oncological effects,analyzed their molecular mechanisms and their contribution to different stages of lung cancer development,and provided scientific theoretical basis for local authorities to formulate targeted measures.To maximize the regional environmental quality and reduce the health risks of the people.