Research On Mussel-inspired Construction Of High Strength Aartificial Cartilage/Bone Integration Material And Biotribology

Artificial joint replacement is one of the effective methods for the treatment of joint injury.However,there are some problems in traditional joint replacement such as serious wear and aseptic loosening.In recent years,polyvinyl alcohol(PVA)hydrogel and its composite materials have attracted wide attention as a new artificial cartilage replacement material.However,the low bonding strength between PVA hydrogel and hard substrate and the lack of mechanical strength of PVA hydrogel are the two main problems limiting its application in artificial joint replacement.Therefore,it is of great significance to construct the bionic articular cartilage material with high strength and friction resistance and the bionic articular cartilage/bone integration material with high bonding strength.Based on the inspiration of mussel,the high strength PVA/HA/PAA/PDA composite hydrogels of mussel-inspired were constructed by freezing,thawing,annealing and so on.And then the biomimetic cartilage/bone integrated material of mussel was obtained.Biomimetic cartilage material(high-strength PVA/HA/PAA/PDA composite hydrogel)was a three-dimensional porous network structure,with good hydrophilicity,swelling and high water content.Polydopamine(PDA)nanoparticles improved the homogeneity and compactness of bionic cartilage materials.PDA nanoparticles significantly improved the mechanical properties of bionic cartilage materials.The tensile strength of the bionic cartilage material reached9.963MPa and the elongation was 666.689%,which still had good creep resistance under large loads.The biomimetic cartilage material had a good elastic recovery ability in the low strain stage,counteracted the impact when the frequency changed,and maintained good elasticity and thermal stability even if the temperature increased.The combination of mussel-inspired chemical adhesion and laser mechanical chimerism effectively improved the bonding strength between the bionic cartilage material and the hard bone base,and played a role similar to the adhesion function of mussels byssus.The bonding strength between the bionic cartilage material and the hard bone base reached 52.68Mpa,and the interfacial toughness between the bionic cartilage material and the hard bone base reached 3.9×10~3J/m~2.Sliding friction experiments showed that PDA nanoparticles enhanced the deformation resistance of biomimetic cartilage materials,and reduced its friction coefficient.The sliding friction of biomimetic cartilage materials conformed to the classic hydrogel adsorption-exclusion model.The torsion friction experiment showed that the friction torque of bionic cartilage increased with the increase of normal load,while the equivalent friction coefficient decreased.The friction torque increased with the increase of torsion angle.At the initial stage of friction,the friction interface was in the state of full sliding.With the increase of cycle period,the friction interface gradually became stick-slip mixing state.The swing friction experiment showed that the swing friction coefficient of bionic cartilage decreased first and then increased with the increase of normal load.The swing friction coefficient increased with the increase of swing angle.In this paper,there are 64 figures,9 tables and 96 reference articles.