Preparation And Properties Of Polyampholyte Hydrogels For Biomimetic Articular Cartilage

Polyelectrolyte hydrogels with good biocompatibility and three-dimensional porous structure similar to natural articular cartilage have good application prospects in biomedical fields such as cartilage repair.For the development of new materials,considering the poor mechanical properties and friction properties of polyelectrolyte hydrogels,this study combines structural bionics,material bionics and performance bionics to prepare new materials and modify them,hoping to achieve polyelectrolyte hydrogels with excellent overall properties.In this paper,acrylic acid?AA?,acrylamide?AAm?,Methacrylatoethyl trimethyl ammonium chloride?MTAC?and poly?p-styrenesulfonate??PSS?are used as raw materials.The polyampholyte?PA?hydrogel was prepared by ultraviolet irradiation and subjected to nano-composite and double-crosslink modification.The microstructure,tensile properties,rheological properties and frictional wear resistance of hydrogels were discussed.In terms of structural bionics and material bionics,all three hydrogels have a three-dimensional porous network structure and a composition similar to natural articular cartilage.For bionics of mechanical properties,both modification methods effectively improve the tensile strength and ductility of PA hydrogels,and the modification effect of nano-composites against tensile strength is better.The hydrogel material has better ductility after immersion in the Fe³⁺solution.For bionics of friction performance,the lowest friction coefficients of PA,PA-GO and PA-Fe³⁺hydrogels measured under medium load?5N?and lubricated by calf serum were0.035,0.02 and 0.018,respectively,indicating that both modification methods can effectively improve the surface lubrication properties of hydrogels.For bionics of wear properties,the surfaces of PA,PA-GO and PA-Fe³⁺hydrogels are very smooth with a surface roughness of:PA>PA-GO>PA-Fe³⁺?2.81>1.33>0.05?m?.