Study On Oxidative Dehydrogenation Coupling Of 3,4-dihydro-1,4-benzoxazin-2-ones To Construct Carbon-heteroatom Bonds

This thesis is mainly divided into two parts.The first part briefly summarizes the research progress of the C-H functionalization of quinoxaline derivatives in recent years.It mainly includes two aspects:(1)C-H functionalization of quinoxaline-2(1H)-one derivatives;(2)C-H functionalization of 3,4-dihydroquinoline-2(1H)-one derivatives.The second part details the research finding on oxidative dehydrogenation coupling reaction of 3,4-dihydro-1,4-benzoxazin-2-one for the construction carbon-heteroatom bonds during the author's graduate period.The main contents are summarized as follows:1.Chapter 2 details the copper-catalyzed oxidative phosphonation of 3,4-dihydro-1,4-benzoxazin-2-ones.This reaction provides a new opportunity for the synthesis of potentially bioactive ?-aminophosphonates.2.Chapter 3 details the peroxidation of 3,4-dihydro-1,4-benzoxazin-2-one under catalyst-free reaction conditions.The resulting peroxide products can be further transformed into various substituted 3,4-dihydro-1,4-benzoxazin-2-one derivatives with potential biological activity.