Diclofenac Sodium Intercalated CaAl-LDH And Its Application In PLA

LDHs nanomaterials and electrostatic spinning materials can be used to prepare slow and controlled release preparations.They are very attractive substrates or main bodies,which can be used to improve the encapsulation rate of drugs and effectively reduce the sudden release of drugs.In this study,a new drug carrier was prepared to achieve better controlled release effect by combining the performance advantages of the two materies.The model drug sodium diclofenac(DS)was successfully inserted into the layers of calcium aluminum hydrotalcum(CaAl-LDH)using the model drug as a guest molecule,and a primary slow-release structure was obtained.Then blended with the spinning fiber to prepare an inorganic/organic secondary slow-release system to achieve the purpose of continuous drug release.The main research contents are as follows:Part ?: Explore the influence of hydrothermal method,co-precipitation method and different calcium-aluminum ratio on the morphology and crystallinity of the product.The results showed that the co-precipitation method could be used to prepare CaAl-LDH with higher crystallinity and single crystal phase.CaAl-LDH and the interlayer distance gradually increased with the increase of the calcium-aluminum ratio.These nanosheets were stacked on each other to form a regular hexagonal layered structure.Finally,when the ratio of calcium to aluminum was 3/1,which showed that the morphology and performance of the CaAl-LDH was the best.And its pore volume and average pore size were respectively 0.031192 cm/g and 24.123 nm.Part ?: CaAl-LDH as the carrier,the Asprin and DS were selected as the model which were loaded by adsorption method and coprecipitation method respectively.XRD,FITR and SEM were used to characterize the compositions.It was found that both the Asprin-LDH prepared by coprecipitation method and the DS-LDH prepared by adsorption method were failed to intercalate.In contrast to the CaAl-DS-LDH prepared by the co-precipitation method,the datas indicated that the drug had been successfully insertedinto the interlayer.Besides,the intercalation of DS affected the density of electron clouds around the calcium and aluminum elements on the laminate,but no new chemical bond was formed.In addition,the results proved that Bhaskar model fited well with the dynamics of DS released from nanocomposites.Part ?: Based on the previous research,the drug-loaded hydrotalcite(LDH-DS)was combined with the electrospun porous fiber membrane to prepare a secondary sustained-release structure to achieve the purpose of sustained drug release.The LDH-DS was added to the spinning solution,followed by homogeneous stirring and co-spinning to prepare PLA nanofiber membranes.The datas showed that the LDH-DS had been successfully embedded into the fiber membrane and the inside structure of the hydrotalcite was solid.In addition,the in vitro release test showed that the nanofiber membrane embedded with LDH-DS effectively reduced the burst release of the drug,and could prolong the release time of the drug.Porous fibers could better fix drugs and delay the release of drugs to a certain extent.