Studies On Asymmetric Aza-michael Addition Catalyzed By Camphor Sulfonyl Hydrazine And Synthesis Of Imine Catalyzed By Novel CeO₂-MoS₂ Composite

Whether in China or in all over the world,the chemical industry is one of the pillar industries of the national economy.In the entire chemical industry,more than 90%of the processes are more or less related to catalytic action.The development of catalytic science as the core technology of the chemical industry related to the level of industry technology in a country directly.The subject of catalysis has been paid much attention,especially the two fields of asymmetric catalysis and nanomaterial catalysis have attracted increasing attention from scientists.In this thesis,the research work focused on the preparation and application of chiral camphor sulfonyl hydrazine?Ca SHs?catalysts and the novel Ce O₂-Mo S₂ composite materials.The two pasts are as follows:The first part of the work was to synthesize a chiral camphor sulfonyl hydrazine?Ca SHs?catalyst to catalyze the aza-Michael addition/cyclization reaction between N-PG hydroxylamine and enals,and a series of chiral 5-hydroxyisoxazolidines with good reactivity and stereoselectivity were synthesized.Compared to other reported methods for synthesizing isoxazolidines,chiral camphor sulfonyl hydrazine can be used as catalyst to synthesize isoxazolidines in one step.It enriches the diversity of methods for the synthesis of chiral 5-hydroxyisoxazolidines and optimizes the synthetic route.In the second part of the work,a series of novel Ce O₂-Mo S₂ composite materials were designed and synthesized for the synthesis of a series of imine efficiently,quickly.The novel Ce O₂-Mo S₂ composite catalyst is environmental friendly,easy prepration,inexpensive,and It has good catalytic performance.Therefore,it is necessary to develop a new composite catalyst to efficiently and quickly catalyze the synthesis of imines.