Clinical Retrospective Analysis Of Arterial Ultrasound In Patients With Takayasu Arteritis

Takayasu Arteritis(TA)is a chronic,multiple aorta and its branches,nonspecific inflammation,coronary artery and pulmonary artery can also be affected,its etiology is unknown,the affected artery stenosis or occlusion,lesions caused by artery ischemic clinical performance of the organization.Objective:To retrospectively collect and analyze the clinical characteristics of TA and provide more information for early detection,clinical diagnosis,treatment and prognosis.Methods:109 patients with TA were enrolled in the study from January 2010 to October 2017 in the China-Japan Union Hospital of Jilin University.All patients were diagnosed as TA by specialists according to the criteria of National Institutes of Health in 1990.the demographic data,clinical manifestations,laboratory indicators,clinical classification and peripheral vascular ultrasound in patients were collected and analyzed.Result:1.General condition and clinical condition of TA patientsAmong the 109 patients,21 were males(19.3%),88 females(80.7%),and the ratio of males and females was 1:4.2.The average age of the onset was 35.85 ±14.40 years.The highest incidence was among patients aged 40 and below.The most common initial symptoms of TA patients were dizziness.In the first episode,chest tightness was statistically significant between men and women(P=0.02).The most common type of clinical classification is the broad type,followed by the first arm artery,the thoracic and abdominal arterial and pulmonary artery type.Among the 109 patients,there were 65 anctive patients and 44 inactive patients.The ESR was increased in 65 patients(59.6%),including 72.3% of active patients and 40.9% of inactive patients,fifty patients(45.9%)showed increased CRP,53.8% of whom had elevated CRP in active patients and 34.1% in inactive patients.The difference between the active period and the inactive period of ESR and CRP in patients with TA was statistically significant(P=0.001,P=0.042).2.The distribution of various ultrasonographic manifestations in patients with TAThe most common peripheral artery involved in TA patients is the common carotid artery,followed by the inferior clavicular artery and the internal carotid artery.The wall in active patients was thicker than that in inactive patients,the affected artery wall thickness in the activity of patients with TA and the activity between the difference was statistically significant(P=0.001).The tube wall thickness of the ESR group was higher than that of the normal ESR group,and the difference between the two groups was statistically significant(P=0.003);The wall thickness of the CRP positive group was higher than that of the CRP negative group,and the difference between the two groups was statistically significant(P=0.01).The most common ultrasound manifestation was stenosis.Stenosis and occlusion are most common in the common carotid and subclavicular arteries,dilatation or aneurysm formation and concomitant manifestations in the abdominal aorta and the common carotid artery.Conclusion:1.In TA patients,stenosis is the main manifestations,which are most happened in carotid and subclavian arteries.The most frequently involved peripheral artery of TA is the carotid artery,followed by the subclavian artery.2.In TA patients,the blood vessel wall thickness is related to the active period,the level of ESR and CRP,which are helpful for the diagnosis of clinical TA activity period.