The Clinical Application Of Ultrasound Screening Of Unchal Translucency And Nasal Bone In The Early Pregnancy

Objective:1.To investigate the relationship between fetal nape transparent layer thickening and fetal nasal bone deletion in early ultrasound screening and chromosome disease.2.Advantages of ultrasound combined screening in the early pregnancy of Down syndrome in prenatal screening.3.To investigate early detection of fetal abnormalities by early ultrasound screening and early diagnosis.4.To establish the standardized ultrasonic surface of the fetus in the early pregnancy of our hospital,and to study the contents and clinical significance of these sections.5.Prenatal screening is selected for clinical selection,prenatal diagnosis is further carried out,and prenatal treatment provides favorable reference.Method:1.From January 2016 to September 2017,8651 cases of prenatal examination were carried out in our hospital.Eliminate the cause of the fetal position,the obesity of the pregnant women and the cases of loss of visits,we get a total of 5637 cases of effective cases,the age was 18~44(29.5 + 4.2)years old.2.By consulting the obstetric cases in our hospital,the case of the prenatal diagnosis center,the case and telephone follow-up of the children’s health department The pregnancy outcome was obtained and the newborn was followed up to 6 months postpartum.3.The GE-E6 and Philips-IU22 color Doppler ultrasonic diagnostic apparatus were used,and the frequency of the probe was 3.5-5.0MHs.After abdominal scanning,CRL was selected from 45 mm to 84 mm.,estimating gestational age.In accordance with the standards recommended by the British fetal medical foundation,NT is measured accurately.4.Through the early screening experience of our hospital for many years,combined with the British fetal foundation and the mid pregnancy system screening,we developed a set of early screening ultrasound standard section.5.SPSS 15 software is used for data processing.Counting data is expressed by rate,and X2 test is used.Compared with the corrected X2 test.The test level is α= 0.05.Result:1.Of the 5637 cases,131 cases of nasal bone loss and / or NT thickening(55 cases of nasal bone loss,86 cases with NT thickening),5506 cases of normal nasal bone and NT.The rate of chromosome abnormality in nasal bone loss and / or NT thickening is12.21%(16/131).The abnormal rate of nasal bone and NT normal chromosome is0.34%(19/5506),and the difference between them is P < 0.05.2.Of the 5637 cases,the fetal NT values were normal in 5551 cases 98.47%(5551/5637),and NT thickening in 86 cases(86/5637).The rate of chromosomal abnormality in thickened NT was 11.62%(10/86),the abnormal rate of normal NT chromosome was 0.25%(25 /5551),and the difference between them is P < 0.05.3.Of the 5637 cases,there were 5582 cases of fetal nasal bone 99.04%(5582/5637),and 55 cases of nasal bone loss0.97%(55/5637).The abnormal rate of chromosome deletion in the nasal bone was 23.63%(13/55),and the chromosome abnormality was0.39%(22/5582)in the nasal bone.and the difference between them is P < 0.05.4.There were 10 cases of nasal bone loss with NT thickening,of which 7 were chromosomal abnormality,and the rate of examination was 70%(7/10).5.The highest detection rate of 21-trisomy was 64.28%(9/14),and the lower detection rate of small chromosome and sex chromosome lesions was 30%(5/15)and 0%(0/3), respectively.6.32 cases of severe structural malformation were screened at early stage,131 cases of early pregnancy screening of abnormal NT of nasal bone,structural malformation rate of chromosomal abnormality 28.57%(10/35),and the abnormal rate of structure in the normal chromosome group was 1.52%(2/131),and the difference between them is P <0.05.conclusion:1.NT thickening and nasal bone loss have high clinical value for early detection of fetal chromosomal abnormalities and structural abnormalities.It can be used as an important index for screening fetal malformations in early pregnancy.2.The combination of NT thickening and early ultrasonic screening of nasal bone loss is more effective than single screening.3.NT thickening and loss of the nasal bone,the risk of chromosomal abnormalities increased,and the most common of the chromosomal abnormalities was the 21-trisomy.4.Early ultrasound screening of fetal NT thickening and or loss of nasal bone,most of the system structure screening in the middle pregnancy is associated with congenital heart malformation.5.In patients with NT thickening and or missing the nasal bone,a walking prenatal diagnosis should be taken to eliminate chromosomal abnormalities and eliminate structural malformations during the middle pregnancy.6.Establish a section of a relative perfection early fetal screening,screening can not only early fetal malformation,but also can let us grasp the process of early embryonic development,know what is a manifestation of what is normal and what is abnormal,which often need different clinical treatment immediately,provide important help for clinical prenatal diagnosis.