| BackgroundMale breast cancer is a rare malignancy with less than 1% of breast cancer.In male malignancies,the incidence is less than 1%.Although the incidence is relatively low,the degree of malignancy is high,and the incidence rate has been rising,which has seriously affected the physical and mental health of men and should be given sufficient attention.Around the 14 th century,the British doctor John Arderne described male breast cancer for the first time,and people began to notice the disease.In the United States in 2015,2,350 men were diagnosed with breast cancer and 440 died,therefore,male breast cancer is extremely malignant and has a high mortality rate.At present,the principle of treatment of male breast cancer is mainly based on female breast cancer,however,the physiological characteristics of male breast cancer are still different from those of women.For example,male breast tissue is less,there is no lobular structure,lymphoid tissue is abundant,and lymph node metastasis is easy to occur.Therefore,relative to female patients,the prognosis is poor.ObjectiveTo analyze the basic pathological features and clinical data of 52 cases of male Breast cancer(MBC)to improve the understanding of male breast cancer.MethodsCollected clinical and pathological data of 52 cases of male breast cancer admitted to the First Affiliated Hospital of Zhengzhou University,the Second Affiliated Hospital of Zhengzhou University and Zhengzhou Central Hospital from January 2002 to February 2018,and retrospectively analyzed the clinical data of all clinical Pathological data to establish a database to analyze its epidemiology,clinical manifestations,diagnostic methods,pathological changes,treatment methods and prognosis.Results1.The incidence of breast cancer in men aged 12 to 82 years,with a median age of 61.5 years,27 on the left and 25 on the right,with a ratio of 1.08: 1.The primary clinical manifestations of breast cancer were breast lumps.2.48 patients underwent surgery,of which 35(72.9%)patients underwent modified radical mastectomy,3(6.3%)underwent radical mastectomy,10(20.8%)underwent mastectomy,the remaining 4 patients underwent chemotherapy alone or endocrine therapy.3.Clinical stage I was 13 cases(25.0%),stage II was 19 cases(36.5%),stage III was 11 cases(21.1%),stage IV was 9 cases(17.4%),and 48% of patients had lymph node metastasis.4.The main histological types were non-specific type of invasive ductal carcinoma(73.1%).Histological grade: Grade I in 2 cases(5.3%),Grade II in 32cases(84.1%),Grade III in 4 cases(10.6%).ER positive in 48 cases(92.3%),PR positive in 43 cases(82.7%),AR positive in 39 cases(75.0%).The molecular typing were 27(51.9%)in Luminal A,22(42.3%)in Luminal B and 3(5.8%),HER-2overexpression was not seen.5.The differences of survival rates were analyzed by log-rank test.There were significant differences in the survival rates of different lymph node status,TNM staging,molecular typing,histological grade,adjuvant chemotherapy and endocrine therapy.There was no difference in the survival rates of different tumor locations,ages,histological types,treatment and adjuvant radiotherapy.After COX multivariate regression analysis,lymph node status,molecular typing and chemotherapy were independent factors that affected the prognosis.Concludes1.Male breast cancer is rare and the age of onset is concentrated in the elderly.Non-specific types of invasive carcinomas are the main pathological types.Luminal A and Luminal B are common molecular types.2.Lymph node,TNM staging,molecular typing,histological grade,adjuvant chemotherapy and endocrine therapy affect the prognosis of patients,lymph node status,chemotherapy and molecular typing were independent factors that affected the prognosis. |
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