Analysis Of Clinical And Pathological Characteristics Between Male And Female Patients With Breast Cancer

Objective:A single institute review of the clinical presentation, pathological and molecular biological characteristics between male breast cancer patients and female breast cancer patients, collection comprehensive data on clinicalpathological presentation and management of male breast cancer may help to optimize the Clinical care. Methods: Male and female breast cancer patients in StageⅠ～Ⅲwere enrolled from January 2002 to June 2009 in Affiliated cancer Hospital of Xin jiang Medical University, Including 39 male patients and 156 female patients, clinical and pathological feature were analyzed in two groups, including age at first diagnosis, the interval between initial symptom and first diagnosis, histologic type, tumor size, axillary lymph node status, cTNM stage, estrogen receptor (ER) status, progesterone receptor (PR) status and epidermal growth factor receptor 2 (Her-2). Results:Compared with female, male breast cancer patients were composed of larger proportion of elder patients (especially over 50 years old), (P<0.001) , longer interval between initial symptom and first diagnosis (P=0.031), More postive axillary lymph node involvement (P=0.036), More ER, PR positive ones (P=0.008, P=0.001). StageⅡ,Ⅲaccounted for main parts in male breast patients (P=0.042). There were larger proportion of subtype patients with ER positive and/or PR positive, C-erbB-2 negative, than subtype patients with ER negative and PR negative, C-erbB-2 positive (P=0.038); There was not significantly different in histologic type and Her-2 status between two groups (P>0.05). Conclusion:The prognostic factors in male breast cancer patients may be worse than those of female breast cancer. It indicated that the key to male breat cancer treatment was early discovery, early diagnosis and individualized treatment.