Correlation Of Anti-TPO And Anti-c-mpl Antibody With Thrombocytopenia In Systemic Lupus Erythematosus Patients

Objective To investigate the correlation of anti-thrombopoietin(TPO)antibody and anti-thrombopoietin receptor(c-mpl)antibody with thrombocytopenia in systemic lupus erythematosus(SLE).Methods Serum samples from 36 SLE patients with thrombocytopenia(group A),26 SLE patients with normal platelet counts(group B)and 11 healthy controls(group C)were collected.Serum TPO,anti-TPO antibody and anti-c-mpl antibody were detected by ELISA.Their correlation with the clinical manifestations and experimental parameters was analyzed.Results(1)Serum TPO level in SLE patients with thrombocytopenia was significantly higher than the healthy control group;Serum anti-TPO antibody in SLE patients was 41.9%,and Serum anti-TPO antibody in SLE patients with thrombocytopenia,SLE patients with normal platelet counts and healthy controls group were 55.6%,23.1% and 0,respectively.The difference among three groups was statistically significant(P <0.05);Serum anti-TPO antibody was significantly different between A and B groups(P<0.05);Patients with positive anti-TPO antibody were more likely to have skin rashes than those with negative one(P <0.05);APTT and PT of the antibody negative group were longer than that of the antibody positive group,and there are statistical differences(P <0.05);There was no significant difference in platelet count,serum TPO,complement C3 and C4,ESR,CRP,anti-dsDNA positive rate,anti-β2-GP1 and SLEDAI scores between anti-TPO antibody positive group and negative group.(2)Serum anti-c-mpl antibody in SLE patients was 25.8%,and in SLE patients with thrombocytopenia,SLE patients with normal platelet counts and healthy controls group were 25%,26.9% and 0,respectively.The differences among three groups was not statistically significant(P>0.05);Serum anti-c-mpl antibody has not significantly difference between A and B groups(P>0.05);Patients with positive anti-c-mpl antibody were more likely to have skin rashes than those with negative one(P <0.05).(3)Serum anti-TPO antibody was positively correlated with serum anti-c-mpl antibody in SLE patients with thrombocytopenia.Conclusion Serum anti-TPO antibodies were elevated in SLE patients with thrombocytopenia,and anti-TPO antibody and anti-c-mpl antibody may play a role in the pathogenesis of SLE-associated thrombocytopenia.