IVF Outcome Of Long Down-Regulation Protocol In 112 Patients With Luteinizing Hormone <2 IU/L

Objective To study the ovarian response and IVF/ICSI-ET outcome of the long Gn RH-aprotocol in those patients with base LH <2 IU/L,so as to explore the correlation of LH as a single index and ovarian reserve.Methods Those patients undergoing IVF/ICSI-ET with the base FSH <10 IU/L from January 2014 to March 2017 were enrolled.According to the age and the base LH level,those patients were divided into four groups,the group A: age ?35 years(25~35 years old)and base LH<2 IU/L(n=88);the group B: age ?35 years(25~35 years old)and base LH 2~5 IU/L(n=226);the group C: age>35 years(36 ~ 42 years old)and base LH < 2 IU/L(n=24);the group D: age > 35 years(36~42 years old)and base LH 2~5 IU/L(n=58).The superovulation rate,the quantity and quality of embryo,and the pregnancy rate were compared.Results The base LH level and LH levels on the down-regulated day and Gn starting day in the group A were significantly lower than those in the group B(P<0.05),while the total dose of Gn in the group A was higher than the group B(However,P>0.05).The E2 level on the day of h CG injection,the number of ?14 mm follicles,the retrieved oocyte number,the number of 2PN and the number of high quality embryos in the group A were significantly lower than those in the group B(all P<0.05).The FSH/LH ratio in the group A was 4.06.The base LH level and LH levels on the down-regulated day and Gn starting day in the group C were significantly lower than those in the group D(P<0.05),while the total dose of Gn in the group C was higher(However,P>0.05).There were no significant differences in the E2 level on the day of h CG injection,the number of ?14 mm follicles,the retrieved oocyte number,the number of 2PN and the number of high quality between the group A and group B(allP>0.05).The FSH/LH ratio in the group C was 4.23.Interestingly,there were no significantly differences in the LH level on the day of h CG injection,the rate of biochemical pregnancy and the rate of clinical pregnancy between the group A and group B,or between the group C and group D(both P>0.05).Conclusion The age ?35 and base LH <2 IU/L,as two parameters of ovarian reserve function,can be used as clinical references of ovarian stimulation protocols.