| Objective:Objective to explore the correlation between bone mineral density(BMD)and TCM Syndrome Types in patients with postmenopausal diabetes mellitus(DM)Method:(1)selected from June 2015 to November 2016 in 187 cases of outpatient and inpatientdepartment of endocrinology of Shanxi Province people’s hospital;(2)using a questionnaire to collect the basic information of patients,the TCM syndrome type through the questionnaire and the method of TCM,dual energy X-ray bone density determination of bone mineral density in patients with absorption absorptiometry,Center Laboratory of saccharification hemoglobin,C peptide,insulin release and blood calcium,blood phosphorus,alkaline phosphatase and other biochemical indicators;(3)using SPSS13.0statistical software package,count data expressed by frequency,different data groups were compared by chi square test;The measurement data were expressed by mean±standard deviation,and the correlation between the parameters was analyzed by multiple regression analysis.The level of α=0.05,which indicated that the difference was significantResult:(1)The general information187 cases of postmenopausal patients with diabetes,with an average age of(60.5 ±6.29),the course of the disease(9.32 ±2.65),age of menopause(51.23 ± 2.68),duration ofmenopause(36.59 ±3.72),production time(2.67±1.22);(2)Distribution regularity of TCM syndromes Postmenopausal patients with diabetes were divided into five types: heat due to yin deficiency,Qi and yin deficiency,dampness heat and spleen deficiency and qi stagnation and blood stasis,yin and yang two.Among the two Qi and yin deficiency syndrome(59cases)>excessive heat due to Yin deficiency(38 cases)>blood stasis(33 cases)= two deficiency of yin and Yang(33 cases)>damp spleen(24 cases);(3)Results of bone density distribution Bone mineral density determination results 55 cases of bone metabolism in normal bone mass groups,osteopenia group 73 cases,59 cases of osteoporosis group,29.4% of the total respectively,39%,31.6%;After statistics analysis,bone loss,respectively,compared with normal bone mass and osteoporosis were statistically significant,P < 0.05;(4)The relationship between the bone mineral density and TCM syndrome type(1)The TCM syndrome type distribution of bone mass normal group for hot sheng Yin 34 cases,accounting for about 61.8%,the proportion is the largest,proportion of both Yin and Yang deficiency syndrome,at least to 0,damp and hot trapped spleen about 16 cases(29.1%),qi and Yin two virtual 3 cases,accounting for about 5.4%,and qi stagnation and blood stasis in 2 cases accounted for about 3.7%;(2)The distribution of TCM syndrome type in patients with osteopenia group for gas Yin deficiency of 52 cases,accounting for about 71.2%,the largest proportion,two virtual 3cases of Yin and Yang and Yin deficiency hotness in 3 cases for about 4.2%,the least proportion of damp heat trapped spleen about 6 cases,for about 8.2%,9 cases accounted for about 12.2% of qi and blood stasis;(3)Osteoporosis group of TCM syndrome type distribution and 30 cases of Yin and Yang are two virtual are accounted for 50.8%,accounted for the largest share,Yin deficiency in1 case,hotness are accounted for 1.7%,accounted for,at least 22 cases,qi and blood stasis are accounted for 37.3%,gas Yin deficiency of 4 cases,all accounted for 6.8%,damp and hot trapped spleen 2 cases,were accounted for 3.4%;(4)By the statistical analysis of TCM syndrome types have an effect on bone mineral density,chi square value was 97.389,P value is 0.000,P < 0.05,at the same time also has effect on the bone mineral density of traditional Chinese medicine on,chi square value of124.212,P value is 0.000,P < 0.05).(5)TCM syndrome type and bone mineral density and the relationship between the influencing factors(1)TCM syndrome type and age,BMI,and glycosylated hemoglobin,low density lipoprotein is different by the results of variance analysis,P < 0.05,and with age,menopause duration ofmenopause and production time,fasting insulin,fasting C peptide between no statistical difference(P > 0.05);(2)The type of syndrome and bone mineral density,age,course of the disease,BMI,alkaline phosphatase,low density lipoprotein cholesterol,glycosylated hemoglobin after correlation analysis,the results for the age(r =-0.229),course(r =-0.126)and BMI(r =0.216),bone mineral density(r = 0.711),low density lipoprotein cholesterol(r = 0.313),glycosylated hemoglobin(r =-0.338);(6)Bone mineral density and the influence factors of relationship(1)Gycosylated hemoglobin,bone mineral density and age,BMI,low density lipoprotein cholesterol and alkaline phosphatase between the anova statistical differences(P < 0.05),and menopause age,menopausal age,production time,vitamin D,fasting insulin,fasting C peptide has no statistical difference(P > 0.05);(2)Bone mineral density and age,course,BMI,alkaline phosphatase,low density lipoprotein cholesterol,and glycosylated hemoglobin after correlation analysis,the results for the age(r =-0.206),course(r =-0.121)and BMI(r = 0.279),alkaline phosphatase(r =-0.171),low density lipoprotein cholesterol(r = 0.419),glycosylated hemoglobin(r =-0.362)Conclusion:(1)Postmenopausal patients with diabetes bone mineral density and age,course,glycosylated hemoglobin,and alkaline phosphatase is negative correlation,is positively correlated with low density lipoprotein cholesterol,BMI,age,sugar metabolic abnormalities involved in the occurrence of osteoporosis.(2)In postmenopausal patients with diabetes age,duration of disease,glycated hemoglobin,low density lipoprotein cholesterol,there is correlation between BMI and syndrome type of traditional Chinese medicine,TCM syndrome differentiation of secondary indicators;(3)Both Qi and Yin deficiency and Qi stagnation and blood stasis and deficiency of both yin and Yang for postmenopausal main syndromes of abnormal bone metabolism in patients with diabetes,there are significant differences between different types of bone mineral density,suggesting that bone mineral density can be used as objective indicators of syndrome differentiation of traditional Chinese medicine. |
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