Clinical Study On Changes Of Renal Function And Its Influencing Factors In Patients With Type 2 Diabetes After Receiving Contrast Agent

Objective:Retrospective analysis of changes in renal function after coronary angiography in patients with type 2 diabetes mellitus and investigation of contrast induced nephropathy?CIN?in diabetic patients,and to provide reference for clinical prevention of contrast agent nephropathy.Methods:The study subjects were 175 patients who met the following inclusion criteria for coronary angiography?CAG?and?or?percutaneous coronary intervention?PCI?at the First Affiliated Hospital of Guangxi Medical University from January 2015 to December 2016.According to whether type 2diabetes mellitus was diagnosed,it was divided into 80 cases in the diabetic group and 95 cases in the nondiabetic group.Based on whether Contrast Induced Nephropathy occurred 48 hours after coronary angiography was divided into CIN group?within 48 hours of contrast medium,serum creatinine increased by44.2 umol/L or 25%higher than the baseline value?^[1]and non-CIN group.Analysis of changes in serum creatinine?Scr?before and after angiography and its relationship with blood glucose control and renal function before receiving contrast media.Results:1.There was no significant difference in serum creatinine levels between the diabetic group and the non-diabetic group before and after coronary angiography?P>0.05?.In each group,there was no significant difference in serum creatinine after contrasting with pre-contrast serum creatinine?P>0.05?.2.There was no significant difference in the difference of creatinine and percentage of creatinine between the diabetic group and the non-diabetic group after coronary angiography?P>0.05?.3.The incidence of CIN was 3.75%?3/80?in the diabetic group and 3.16%?3/95?in the nondiabetic group.There was no significant difference between the two groups?P>0.05?.4.The changes of serum creatinine before and after contrast in CIN and non-CIN groups.There was no significant difference in serum creatinine levels between the two groups?P>0.05?.The levels of serum creatinine,difference of creatinine and percentage of creatinine in the CIN group were significantly higher than those in the non-CIN group?P<0.05?.?P<0.05?.5.There was no significant correlation between serum creatinine changes and FPG,2hPG,HbA1c,UA and ccr before coronary angiography?P>0.05?.6.The level of FPG,2hPG,HbA1c,Scr,UA and ccr before coronary angiography had no significant logistic regression relationship with the occurrence of CIN?P>0.05?.Conclusion:1.CIN can occur in both type 2 diabetic and non-diabetic patients after angiography.The incidence rates were 3.75%and 3.16%,respectively.2.The change of serum creatinine after angiography may not be related to pre-contrast FPG,2hPG,HbA1c,UA and ccr.3.CIN after angiography may not be related to pre-contrast FPG,2hPG,HbA1c,Scr,UA,or ccr.4.Full hydration and other pretreatment before angiography and the choice of isotonic non-ionic contrast agents may be beneficial in preventing and reducing the incidence of contrast induced nephropathy in type 2 diabetic patients.