Correlation Analysis Between Serum CTRP3 Level And Gensini Score In Patients With Coronary Atherosclerotic Heart Disease And Complicated With Abnormal Glucose Metabolism

Background and objective:With the improvement of people’s quality of life,the morbidity and mortality of coronary atherosclerotic heart disease(CHD)and type 2 diabetes mellitus(T2DM)increase day by day,and the proportion of CHD with abnormal glucose metabolism is also high.About 25%of the patients also had T2DM.Diabetes patients are 2-4 times more likely to develop coronary heart disease than the general population,and the proportion of diabetic patients dying from cardiovascular disease,mainly coronary artery disease,is about 75%[1].Coronary artery lesions in patients with coronary atherosclerotic heart disease complicated with abnormal glucose metabolism were more extensive and rapid.One quarter of the patients developed acute coronary syndrome(ACSA)and a third of them had cardiogenic shock.Compared with normal glucose metabolism,the risk of death was significantly increased in patients with abnormal glucose metabolism,and the risk of sudden cardiac death increased threefold.Mortality in patients with acute myocardial infarction(AMI)also increased 2-3 times as compared with patients with normal glucose metabolism[2].Therefore,to improve the understanding of coronary atherosclerotic heart disease and abnormal glucose metabolism,strengthen the clinical comprehensive management of coronary heart disease patients with abnormal glucose metabolism,It is of great significance to reduce the incidence and mortality of ischemic cardiomyopathy caused by cardiovascular disease,especially coronary artery disease,and to improve the quality of life and prognosis of the patients.In recent years,a highly conserved family of proteins homologous to adiponectin(APNs)has been found,namely Clq-/TNF-related protein(CTRPsN),which includes CTRP1 to CTRP15,and each member has different tissue expression and biological functions.Studies have shown that CTRP3 plays an important role in cardiovascular diseases such as glucose and lipid metabolism,hypertension,atherosclerotic heart disease,myocardial remodeling after myocardial infarction,and can reduce the risk of cardiovascular disease.However,the specific mechanism of the role of CTRP3 has not been fully elucidated.The serum levels of Clq/tumor necrosis factor-associated protein 3(CTRP3)in patients with coronary atherosclerotic heart disease(CHD)and coronary atherosclerotic heart disease(CHD)complicated with type 2 diabetes mellitus were measured.To explore the relationship between CTRP3 and coronary artery disease and coronary artery disease with abnormal glucose metabolism in patients with Gensini score and possible mechanism,it is expected to provide a new idea for the diagnosis and treatment of cardiovascular disease,especially coronary heart disease with glucose metabolism abnormality.Methods:In this study,23 patients with CHD confirmed by coronary angiography(CAG),17 patients with T2DM with CHD and 20 patients with T2DM confirmed by oral glucose tolerance test(OGTT test)were selected.In addition,20 healthy individuals were selected and the fasting serum CTRP3 levels were detected by Elisa.Body mass index(BMI)was also measured Blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FPGN),triglyceride(TG),total cholesterol(TC)were collected.The data of smoking history,hypertension history and family history were collected.The database was established with SPSS 22.0 and analyzed statistically.Among them,the measurement data are all expressed in the form of X±S,T test was used between the two samples,and the comparison of the mean numbers of multiple samples was based on the single factor analysis of variance.Linear regression and multiple stepwise regression analysis showed the correlation between serum CTRP3 and other indexes.P<0.05,there was significant difference.P<0.01,the difference was statistically significant.Results:(1)the serum CTRP3 level in CHD group,T2 DM group and CHD T2 DM group was significantly lower than that in HC group,and the serum CTRP3 level in CHD T2 DM group was significantly lower than that in CHD group and T2 DM group(P<0.05).(2)the level of serum CTRP3 was negatively correlated with HbAlcand TG,and positively correlated with HDL-c.(3)the serum CTRP3 level was negati-vely correlated with the Gensini score of coronary stenosis in CHD and CHD T2 DM patients,and there was a significant difference between the two groups(P<0.05).Conclusion:The level of CTRP3 in T2DM group and CHD group was lower than that in HC group,suggesting that CTRP3 not only participates in glycolipid metabolism,but also plays an important role in the occurrence and development of arteriosclerotic cardiovascular disease(ASCVD).The decrease of CTRP3 level becomes abnormal in glycolipid metabolism.Independent risk factors for many diseases,such as atherosclerotic heart disease.The level of CTRP3 in the combined group was significantly lower than that in the other three groups,suggesting that CTRP3 might be involved in coronary heart disease and its risk factors to achieve multiple coronary protection.The level of serum CTRP3 in CHD group was significantly lower than that in T2DM group,and negatively correlated with the degree of coronary artery lesion(Gensini)score,suggesting that CTRP3 was related to the degree of coronary artery disease and was a predictor of coronary artery lesion degree.Combined with abnormal glucose metabolism can reduce the level of serum CTRP3 in patients with CHD and increase the severity of coronary artery disease.CTRP3 plays an important role in many diseases,such as glucose metabolism disorder,atherosclerotic heart disease and so on.It provides a new target and new idea for the treatment of atherosclerotic heart disease,especially in patients with glucose and lipid metabolic disorder.