Analysis Of Clinical Characteristics Of Inflammatory Bowel Disease Complicated With Anemia And Evaluation Of Therapeutic Efficacy Of Iron Sucrose

PurposeObjective To explore the clinical characteristics of inflammatory bowel disease complicated with anemia and evaluate the therapeutic efficacy of iron sucrose from morbidity,Cause of disease,risk factors.To improve the clinical symptoms of patients with inflammatory bowel disease,reduce the number of days in hospital and improve the long-term prognosis.MethodsBy using the method of retrospective study and clinical experiment,the clinical characteristics of the June 2012-June 2016 in the First Affiliated Hospital of Anhui Medical University and Chaohu hospital of Anhui medical university first diagnosed IBD patients.1.Risk factors:Divide the research object into ulcerative colitis and Crohn’s disease groups.Compare UC and CD incidence of anemia,further determining whether the type of IBD is associated with concurrent anemia.(2)The tow groups were divided into severe anemia group,non-severe anemia group and non-anemia group,compared each group with patients age,gender,BMI(Body Mass Index),smoking history,drinking history,pathological changes,disease activity and so on,further determining IBD complicated with anemia and the relationship between these factors.Furthermore,the relationship between IBD complicated with severe anemia and these risk factors were further determined.2.Anemia causes:(1)The collection for the first time on the research object of routine blood,Iron metabolism,folic acid,vitamin B12,the research object of the case information,comparative analysis of Iron deficiency anemia Iron-deficiency anemia(IDA)group,canemia of chronic diseases(ACD)group,Iron-deficiency and chronic diseases(ID + ACD)group and the number of the other groups.(2)To further analyze the causes of anemia among patients in other groups,and to determine whether folic acid,vitamin B12,reticulocyte,and immunological indicators are abnormal.3.Iron sucrose treatment:(1)The collection to be admitted to hospital for the first time the IDA patients as the research object,record the hemoglobin(HB),ferritin,mean corpuscular volume(MCV),transferrin saturation and the calculation of avalue.(2)The patiens in experimental group were given intravenous iron sucrose treatment and the patients in control group were given ferrous succinate,a week after week after treatment record again the object of study of HB,ferritin,transferrin saturation,the MCV.Calculate the bit value again.The changes of the above indicators were compared between the two groups before and after treatment,and the adverse reactions and conclusions were obtained.ResultThis study collected 200 IBD patients,including anemia in patients with UC incidence rate was 31%;the incidence of anemia in patients with CD 65.85%,UC and CD with age,the incidence of anemia were significantly different(P< 0.05)Multivariate analysis showed that smoking history,drinking history,number of lesions and disease activity were risk factors of UC and CD with anemia(P < 0.05),further study on the causes of anemia found an important reason of folic acid,vitamin B12 and etc.cause anemia.Iron sucrose treatment a week after treatment of IDA patients with HB,ferritin,transferrin saturation,median MCV were increased to 98g/L,35mg/dl,28%,84 fl,compared with before treatment was statistically significant(P< 0.05),found no adverse reaction.ConclusionIBD with high incidence of anemia,more risk factors,iron sucrose for IBD with anemia has a better therapeutic effect.