Observational Study Of The Formula For Tonifying Kidney And Vein To The Nephrasthenia Syndrome In Patients With Morning Hypertension

Backgrounds: With a new Times coming and the quickening development of the aged society,the population to the patients in hypertension of the Olds and morning hypertension is gradually growing up,and it is becoming a clinical focus on the control of the blood pressure(especially the morning blood pressure)in the Olders.The Morning hypertension is an abnormal phenomenon of blood pressure fluctuation,with the excessive elevation of the blood pressure in the morning times.With the excessive elevation of the morning blood pressure in a long time,it will take a significant effect on the blood pressure-standarded and its effective management,which will probably cause damage to the target organs and the occurrence of cardiovascular events.According to the research at home and abroad,the control of the morning blood pressure is actually not satisfying with the standard,although the control of the blood pressure in out-patiens' room is qualified to the standard.Meanwhile,it is also considered as an very important factor with the excessive elevation of the morning blood pressure by triggering the cardiovascular events.So it is of great significance with the effective management of the morning blood pressure.And in the aspects of TCM,the hypertension is considered as “xuanyun” or “maizhang” and so on,which can be treated with different methods to the different syndromes.It was also proved that nourish-ingyinand nourishing kindey,controlling blood pressre and nourishing vein is the effective treating principle to the nephrasthenia syndrome in patients with morning hypertension,and the Formula for tonifying kidney and vein is also the effective decoction to the patients with morning hypertension.Based on above,this research is going to explore and trying to prove the facts on whether the Formula for tonifying kidney and vein can improve the rate of blood pressure-controlled,clinical syndromes and the living quality or not.Objective:By observing and analysising the effections of the Formula for tonifying kidney and vein to the nephrasthenia syndrome in patients with morning hypertension,this research is going to find and trying to provide some useful and available evidence-based proofs to the facts on treating the nephrasthenia syndrome in patients with morning hypertension by the decoc-tion,and hoping that what we have done is useful to the exploration and practice,meanwhile,we are trying to prove the facts that Chinese Medicines can also make the BP lower and its advantage on overall compromising.Methods:According to the inclusive standards and exclusive criteria in this research,67 patients with morning hypertension diagnosed as the nephrasthe-nia syndrome are collected in out-patients room and in-patients room of the cardiovascular department in the first affiliated hospital to the Guangxi university of TCM,including 14 males,and 53 females,and all the patients were randomly distributed to the treatment group and control group,the treatment group added the Formula for tonifying kidney and vein free-boiled granules based on the control group with regular Western Medicines.Both groups are treated with 8 weeks,and followed-up by 12 weeks.Measured datas and information are recorded and used to calculate the rate of the blood pressure control,ba PWV and the living quality and so on.Results:(1)Morning blood pressure improvement: The morning systolic blood pressure(SBP)and pulse pressure(PP)in both groups are significantly lower than pre-treated groups(P<0.01)after treated,but the SBP in treat group is more less than that in control group with significant difference(P<0.01),while the morning diastole blood pressure(DBP)in both groups after treated are also significantly lower than before,but 2 groups with no significance,and no significance in follow-up both in SBP,PP and DBP(P>0.05).Meanwhile,the rate of morning blood pressure,pulse pressure and nocturnal blood pressure in treat group are higher than that in control group(P<0.01).(2)ba PWV: The ba PWV in treat group is obviously lower than pre-treat-ed,while no difference in control group both in pre-treated and after treated.So the ba PWV in treat group is obviously lower than that in control group,with significant difference(P<0.01).After follow-up by 12 weeks,the ba PWV in both groups are the same with no intervention of TCM(P>0.05).(3)The points of TCM's syndrome: After intervention by 8 weeks,the points of 2 groups are both lower than before,and the points in treat group are lower than that in control group,with significant difference(P<0.01).While follow-up by 12 weeks,there are no obvious difference on the points of TCM's syndrome in both groups(P>0.05).(4)The points of SF-36: By treated for 8 weeks,the points of SF-36 in 2 groups are both obviously higher than that of before,and more points of SF-36 in treat group with significant difference than that of SF-36 in control group(P<0.01).After no intervention of TCM and follow-up by 12 weeks,no significant difference on the points of SF-36 are found in 2 groups(P>0.05).Conclusion:the Formula for tonifying kidney and vein can make the rate of morning blood pressure control obviously enhanced,ba PWV better,and the patients' living quality improved.The results indicate that he Formula for tonifying kidney and vein can make the morning blood pressure more or less lower,and have an important role in improving the function of blood vessel.