Relationship Between TCM Syndromes And Electroencephalogram In Symptomatic Epilepsy Patients

Objectives:To study the relationship between TCM syndromes and Electroencephalogram(EEG)in symptomatic epilepsy patients,It was studied characteristics of EEG in different TCM syndromes of epileptic patients,to explore whether EEG can be used as a reference index for TCM syndrome differentiation.Etiology of symptomatic epilepsy and factors affecting the prognosis of symptomatic epilepsy were analyzed to guide clinical assessment of the condition,diagnosis and treatments.Methods:A total of 160 patients diagnosed as symptomatic epilepsy in the Department of Encephalopathy at the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2016 to December2017 were selected as the study group.320 normal controls were included in the control group at the same time,and all eligible inclusions were collected.The standard patient's case data and the results of EEG were summarized.the etiology,syndrome characteristics and EEG characteristics of symptomat--ic epilepsy patients were analyzed.According to the control of episodes after treatment,patients were divided into 2 groups with good prognosis group and poor prognosis group.Logistic regression analysis was used to study the prognostic factors that affected the patients.Results:1.General information:There were 160 patients with symptomatic epile--psy,96 were males and 64 were females.The ratio of males and females was3:2,aged from 7 to 88 years old,and average age was(45.39±20.50)years old.The proportion of patients with a prevalence age group was 20-29 years old and?60 years old,and there were 28 patients aged 20-29 years old,accounting for 17.5%,51 patients?60 years old,accounting for 31.88%,especially?60 years old patients were most.The incidence of males and females in each age group was compared,?~2=11.265,P=0.046<0.05,the difference was statistically significant.2.Etiological analysis of 160 patients with symptomatic epilepsy:47 case of strokes(31 cases of cerebral infarction,16 cases of cerebral hemorrhage,accounting for 29.38%;25 cases of brain trauma,accounting for 15.63%;20cases of viral meningitis,accounting for 12.50%;20 cases of cerebral cysticer--cosis,accounting for 12.50%;18 cases of tumor associated(6 cases of meningioma,5 cases of vascular cavernous tumor,4 cases of cerebral aneury--sm,2 cases of glioma,1 case of embryonic dysplastic neuroepithelial neoplasia),accounting for 11.25%;8 cases of craniocerebral surgery,accounting for 5.00%;metabolic encephalopathy 7 Cases,accounting for4.38%;4 cases of febrile seizures,accounting for 2.50%;3 cases of intracranial vascular malformations,accounting for 1.88%;1 case of dystocia at birth,accounting for 0.63%;1 case of multiple sclerosis,accounting for 0.63%;1case of missing hippocampus with hardening,accounting for 0.63%.Univariate logistic regression analysis revealed that cerebral infarction,craniocerebral trauma,viral meningitis,cerebral cysticercosis,and cerebral hemorrhage were related factors in the pathogenesis of symptomatic epilepsy(P<0.05).Multivariate Logistic regression analysis suggested that craniocereb--ral trauma is a more important factors in the etiology of epilepsy(OR=11.250,95%CI:1.746-72.499,P<0.05).4.In this study,among the TCM syndromes of patients with symptomatic epilepsy,there were 75 cases with syndrome of spleen deficiency,whichaccounted for 59.06%,and it was accounted for the largest proportion and was the most common type.5.compare the abnormal electroencephalogram waveforms with Episodes of positive eclampsia and Episodes of eclampsia during seizure period were statistically significant(P<0.05).The abnormal electroencephalogram waveforms of various syndromes during rest periods were statistically significant(P<0.05).After two comparisons,there were statistically differen--ces between obstructing brain resistance,spleen deficiency,and syndromes of liver-kidney yin deficiency in abnormal cerebral electroencephalograms with syndromes.The waveforms of the two charts were all different(P<0.05).There was no difference in the waveforms of the other two types of abnormal EEG(P>0.05).There was no significant difference in the abnormal rate of electroencephalogram among symptomatic epilepsy patients(P>0.05).6.There were differences in the amplitude of different Electroencephalo-grams between patients with Episodes of positive eclampsia and Episodes of eclampsia(P<0.05).After a pairwise comparison,there were significant difference between the liver-heat syndrome and other three types of spleen deficiency syndrome,liver-kidney yin deficiency syndrome,and phlegm-inflammation-combination syndrome(P<0.05),and there was no difference in the amplitudes of the other two types of syndromes(P>0.05).7.Prognostic factors:Univariate analysis showed that oral antiepileptic drug status and drug adherence were factors that affected prognosis(P<0.05).Multivariate logistic regression analysis showed that poor drug adherence was a risk factor for prognosis(OR=5.973,95%CI:2.631-3.559,P<0.05).Conclusions:1.Traumatic brain injury is an important pathogenetic factor in patients with symptomatic epilepsy.2.The abnormal waveforms and amplitudes of EEG have certain referen--ce significance in the TCM classification of symptomatic epilepsy.