| Background As an emerging discipline,Cardio-Oncology develops rapidly.The problems for Cardio-Oncology to solve involve both the damage of cardiovascular due to tumor treatment and the treatment of tumor patients who already have cardiovascular disease.The epidemiological study of the Cardio-Oncology is still blank.Objective This article mainly explores the epidemiological characteristics of Cardio-Oncology,and the purpose of this study is to establish an important basis for further research on the etiology,pathogenesis and treatment of Cardio-Oncology.And we also analyze the relationship between chemotherapy drug use and cardiovascular disease of cancer patients.Methods Choose the patient from February 2011 to March 2017 of our hospital,Use Medi TOCardio system to extract patients' gender,age,admission date,use of chemotherapeutic drugs,and ICD codes.The patients were classified by tumors,heart diseases and drugs,and then analyzed statistically.Results1.There were 38850 patients with malignant tumors,Patients with malignant tumor and heart disease were 10396(26.8%).The number of new heart disease in patients with malignant tumor was 2650(6.8 %).There were 17324 benign tumor patients,Benign tumor patients combined with heart disease 4010(23.1%).The number of new heart disease in patients with benign tumor was 475(2.7%),and the proportion of malignant tumor combined with heart disease and new heart disease is both significantly increased(P<0.05).2.The average age of patients with malignant tumor combined and heart disease is 68.16±10.834,and the proportion of patients aged > 60 years was 76.2%.3.The number of male tumor patients with heart disease is 10396,and 4879 women(46.9%),5517 men(53.1%).The sex ratio is 1:0.88.The number of patients with new heart disease and malignant tumor is 2650,with 1480 males(55.8%)and 1170 females(44.2%),with a ratio of 1:0.79.4.The number of hospitalized patients with malignant tumor combined and heart disease and new heart disease was increasing year by year.The number of hospitalized patients with cancer combined with heart disease increased from 1696 in 2011 to 5129 in 2016,with a growth rate of 203%.The number of patients with new heart disease increased from 333 in 2011 to 937 in 2016,with an increase of 181%.5.The proportion of malignant tumors with different types of heart disease ranged from high to low,hypertension 20.93%,coronary heart disease 5.69%,arrhythmia 4.44%,peripheral vascular disease and stroke 3.88%,cardiac dysfunction 1.87%.The new cardiac dysfunction of malignant tumor patients was not totally 265(accounting for 36.45% of the total number of patients with cardiac dysfunction),and 138 patients with malignant tumor were newly diagnosed with pericardial complications(the site of the combined heart disease pericardial complications was 48.76%).6.The proportion of plasma cell tumor with heart disease is 51.43%,and the proportion of new heart disease is 27.62%.Head and neck cancer combined with heart disease is the lowest of 11.44%,and the new heart disease rate is 1.77%.7.The number of chemotherapeutic drugs is 15079 accounted for 35.2% of the number of tumors,medicine treatment number of new heart disease patients is 1767(occupying take drugs malignant tumor patients for 11.7%),the number of not using drugs malignant tumor with new heart diseases is 3.7%.Patients with chemotherapy drugs have a higher risk of new heart disease(P<0.05).Compared with various chemotherapy drugs,the proportion of patients with new heart disease is higher in patients with cancer of thalidomide and catharanthus alkaloid drugs.Patients taking anti-folic acid show a incidence of new coronary heart disease by 3.9% and new hypertension by 10.7%.In patients with topoisomerase inhibitors,the proportion of new arrhythmias is 3.3%.In patients with progesterone,the new heart failure is 1.5%,new peripheral vascular disease and stroke 1.8%.Conclusion1.The number of new heart disease patients with malignant tumor was higher than that of benign tumor,and the proportion was twice as high as that of benign tumor,which makes sense that the cardiotoxicity truly exists.With older age,male,cardiovascular disease already existing,new cardiovascular disease proportion increase significantly,Risk assessment and monitoring in patients with drug is needed.We should also focus on the treatment of cardiovascular diseases already existing.2.2011-2016 tumor merger and new heart rate on the rise,the tumor patients with the heart diseases will be more and more,more patients in the treatment of cancer patients need both the treatment of tumor and heart disease at the same time.3.we should pay more attention to on-going pericardial complications and heart dysfunction of patients of tumor.4.If thalidomide and catharanthus alkaloid drugs were used,there is a new special attention should be paid to malignant tumor patients of heart disease.If there is use of anti-folic acid drugs,we should pay attention to detect whether there is a new high blood pressure and coronary heart disease,we should pay attention to detect new arrhythmia when topoisomerase inhibitors exist.With existence of progesterone,we should pay attention to check new cardiac dysfunction and peripheral vascular disease and stroke. |
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