Research On The Surface Electric Gastric Parameters And Brain-gut Axis Mechanism Of Patients With Irritable Bowel Syndrome And Functional Dyspepsia

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Research on the electrical parameters of the body surface of irritable bowel syndrome and functional dyspepsia patientsObjective: To investigate the gastrointestinal motility disorder in patients with irritable bowel syndrome(IBS)and Functional dyspepsia(GI),to study the characteristics of gastric electrical map in such patients,to explore the etiology of gastrointestinal symptoms and to give corresponding drugs.Methods: Twenty patients with irritable bowel syndrome in our hospital,40 patients with functional dyspepsia and 20 healthy volunteers were selected as control group.All subjects were discontinued antacids,gastrointestinal motility agents,and calcium antagonists 72 h before the test.12 hours after fasting,body surface electromyography was performed in the early morning.Fasting and postprandial gastric electrical activity parameters were recorded: percentage of normal slow wave rhythm(N%),percentage of bradycardia(B%),percentage of tachygastric(T%),percentage of gastric dysrhythmia(A%),Main frequency(DF),main power(DP),postprandial/preprandial main power ratio(PR).The SPSS 20.0 statistical software was used to perform statistical analysis on the data.The parameters of each group were compared to investigate whether the electrogastrogram parameters ofpatients with irritable bowel syndrome and functional dyspepsia were characteristic.Results: There was statistical difference in preprandial DP(t=2.299,p=0.027)between IBS group and normal control group.The preprandial DP was higher than that of normal control group.The other indexes in IBS group were not statistically significant compared with the normal control group.In the FD group,there was a statistically significant difference in post-prandial N%(t=2.915,p=0.005)and postprandial B%(t= 2.941,p=0.005)compared with the normal control group.The postprandial N% was lower than the normal control group.The postprandial B% was higher than that of the normal control group.There was no statistically significant difference between the other indicators in the FD group and the normal control group.Conclusion:Patients with irritable bowel syndrome and functional dy spepsia have gastric electrical rhythm disorder.Chapter ? study on brain-gut axis mechanism of irritable bowel syndrome and functional dyspepsiaObjective: To investigate the relationship between central nervous system and autonomic nerve-gut nerves by using heart rate variability analyzer,and to reveal the pathophysiological mechanism of intestinal nerve pathway abnormality in patients with irritable bowel syndrome and functional dyspepsia.Methods: Twenty patients with irritable bowel syndrome in our hospital,40 patients with functional dyspepsia and 20 healthy volunteers were selected as control group.All subjects were banned from drinking coffee,tea and alcohol for 12 hours before the test,smoking was banned,and any drugs that could affect blood pressure and heart rate were disallowed to ensure adequate sleep and avoid strenuous exercise.The test was conducted in a comfortable and quiet environment under the test of a body surface heart rate analyzer.Record heart rate frequency domain analysis parameters: low frequency power(LF),high frequency power(HF),low frequency power/high frequency power ratio(LF/HF),low frequency power/low frequency power + high frequency power(LF/LF+HF),High-frequency power / low-frequency power +high-frequency power(HF / LF + HF).SPSS 20.0 statistical software was used to do statistical analysis of the data,and the parameters of each group were compared to investigate whether the autonomic nerves in patients with irritable bowel syndrome and functional dyspepsia had characteristic manifestations in changes of the brain intestine axis.Results: There were significant differences between the three indicators of P1/P2,P1/P1+P2,and P2/P1+P2 in the IBS group compared with the normal control group(t=5.259,p=0.000;t=5.762,p=0.000;t=5.762,p=0.000),in which P1/P2,P1/P1+P2 were higher in the IBS group than in the normal control group,while P2/P1+P2 was lower than in the control group;P1/P2,P1/P1 in the FD group There were statistical differences between the three indicators of +P2,P2/P1+P2 and the normal control group(t=6.206,p=0.000;t=7.615,p=0.000;t=7.615,p=0.000),and its P1/ P2,P1/P1+P2 were higher in the FD group than in the normal control group,while P2/P1+P2 was lower than the control group.Conclusion:1.Patients with irritable bowel syndrome and functional dyspe psia have gastric electric rhythm disorder and autonomic dysfunction(we akened the excitement of sympathetic nerve and vagus nerve,or one of th em),may be the important causes.2.Most patients with irritable bowel sy ndrome and functional dyspepsia have psychological pressure factors.3.Patients with irritable bowel syndrome and functional dyspepsia are affec ted by psycho-psychological factors,and the brain-gut axis causes gastric electrical rhythm disorder through autonomic nerves,leading to abnormal gastrointestinal motility.