Explore Lumbar Fracture And Surgical Trauma Patients At Different Periods IL-6,TNF Levels Change Analysis

Background: the lumbar vertebral fracture and operation trauma patients in proneperioperative bleeding,tissue damage and other adverse conditions,therefore,the level of perioperative cytokines related to close monitoring of patients is important to improve the prognosis of patients.Objective: to monitor the operation of lumbar fracture and trauma patients in different periods of IL-6 and TNF levels,investigated the change law.Methods: 43 patients were selected as object of study in 2014 January-2015 lumbar in January on the same day in our hospital for treatment of fractures,fractures in second days(seventh days before operation,fracture),second days after operation,postoperative(afterfracture in eighth days)and seventh days(thirteenth days after the operation of fracturedetection concentration)in the serum of patients with IL-6,TNF.Results and conclusion: 43 patients in 5 patients due to blood loss is greater than 0.9 L receive blood transfusions,and found that the concentration of serum IL-6 in the process of transfusion,pg > 900 ml,1,TNF concentration > pg · ml-1,270 levels is unusual,so will the 5 patients out of the study;On the second day after fracture,the concentration of il-6 was significantly higher and higher than the normal value of 8.1pg· ml-1,before the operation(B)showed A certain decline but not obvious(t = 0.21,p > 0 0.05).After surgery,the concentration of il-6 reached its peak,and significantly increased(t = 53.27,p < 0.05)before surgery.After the operation,the level of il-6(E)on the second day after surgery(D)and the level of il-6 after surgery showed a continuous and significant decrease(t = 26.17,64.38,p < 0.05).After fracture,the concentration of TNF was significantly higher and higher than the normal value of 11.3pg· ml-1,before the operation(B)had A certain decrease but not obvious(t = 0.43,p>0 0.05).After surgery,the concentration of TNF reached its peak,and the concentration of TNF was significantly higher(t = 20.35,p < 0.05).After surgery,the 2nd day(D)and the 7th(E)TNF concentration were significantly reduced after the surgery(t = 14.73,16.94,p < 0.05).This group of patients with cytokine TNF alpha,IL-6 and pain VAS pain score presents obvious positive correlation(r = 0.689,0.568,P < 0.05).Lumbar vertebral fracture and surgical trauma can lead to patients in the serum IL-6 and abnormal TNF levels increased,peak after completion of the surgery will reduce gradually,perioperative monitoring closely IL-6,the level of TNF change has important value for clinical diagnosis and therapy.