Effect Of Palonosetron Hydrochloride Injection Time Node On Nausea And Vomiting After Partial Thyroidectomy Patients

With the same dose of palonosetron,the effect of palonosetron on postoperative nausea and vomiting of partial thyroidectomy was researched at the different time,in order to investigate the best time of palonosetron injection,and to provide theoretical basis for the clinical application of palonosetron.According to the random number table method,120 patients scheduled for partial thyroidectomy in this hospital were randomly divided into 3 groups,and 40 cases in each group(The Apfel score of the whole patients was 4 points,including female,non-smoking,having a history of motion sickness,opioid analgesics,and the time of the surgery was controlled between 90 ~120 min,the cases of operating time<90min and >120min were removed.)Group A(control group): normal saline 5ml,30 minutes before induction of anesthesia;Group B:Palonosetron hydrochloride injection 0.25 mg/5ml,30 minutes before induction of anesthesia;Group C: Palonosetron hydrochloride injection 0.25 mg/5ml,30 minutes before the end of the surgery.After postoperative 0 to 4 hours,4 to 12 hours,12 to 48 hours,and 48 to 72 hours,patients were followed up and recorded the frequency of nausea and vomiting,and frequency of metoclopramide by intramuscular injection,and the cases of serious adverse reactions.Results:1、The incidence rate and severity of nausea and vomiting from 0 to 4h after operation in group B were significantly lower than those in group A and C(P<0.05).There was no significant difference between group A and group C(P>0.05).2、The incidence rate and severity of nausea from 4 to 12 hours,12 to 48 hours and 48 to 72 hours after operation in group B and C were significantly lower than those in group A(P<0.05).There was no significant difference between group B and group C(P>0.05).3、The frequency of metoclopramide by intramuscular injection: group A was 21 times;group B was 1 times;group C was 12 times.The cases needing re-suture the incision,because of serious postoperative nausea and vomiting: group A was 2 cases and group C was 1 case.Conclusion:1、Under this experimental condition,the injection of the palonosetron hydrochloride injection 0.25 mg/5ml had a positive influences on postoperative nausea and vomiting of patients with partial thyroidectomy.2、Under this experimental condition,The influences of injection of the palonosetron hydrochloride at 30 minutes before induction of anesthesia were better than those at 30 minutes before the end of the surgery.