| Objictive: To explore the role of AIP in the early diagnosis of coronary heart disease by exploring the correlation between the Atherogenic Index of Plasma(AIP)and the coronary artery SYNTAX score in this study.Methods: From January 1,2017 to February 28,2017,the patients who were hospitalized in the cardiology department of Changsha central hospital were treated with chest distress and chest pain as "coronary heart disease",and coronary angiography patients were used to collect the names,sex,age,height,weight,history of high blood pressure,history of diabetes,smoking,and drinking history of all patients.Body mass index,blood fat,liver and kidney function.The study subjects were selected according to the exclusion criteria,and AIP and AIP=log(TG/HDL-C)were calculated according to the results.The results of coronary angiography of all the subjects were collected and divided into coronary heart disease group and control group according to the results of coronary angiography.Coronary artery SYNTAX scores were performed in the patients with coronary artery disease,and the group was divided into three subgroups according to the SYNTAX score system: low risk group(1-22),middle risk group(23-32),and high risk group(≥33).Analysis of general data of coronary heart disease group and control group and blood lipid levels [total cholesterol(Total Choesterol,TC),triglyceride(Triglyceride,TG),high density lipoprotein cholesterol(High Density Lipoprotein cholesterol,HDL-C),low density lipoprotein cholesterol(Low-density Lipoprotein)] Differences;AIP differences between the two groups and coronary heart disease subgroups were compared,and the correlation between AIP and other blood lipid indexes and SYNTAX score was analyzed.Results: A total of 215 patients were included.According to the exclusion criteria,120 patients were included in this study,including 81 males and 39 females,with an average age of(61.09±10.76)years.All patients were divided into coronary heart disease group and control group according to the results of coronary angiography.There were 84 cases of coronary heart disease,including 59 males and 25 females,with an average age of(61.20±10.80)years.The group was divided into three subgroups according to the final SYNTAX score,which were 30 cases in low risk group(1-22),28 in medium risk group(23-32),and 26 in high risk group(≥ 33).There were 36 cases in the control group,including 22 males and 14 females,with an average age of(59.85±9.63)years.1.Comparison of clinical data between coronary heart disease group and control group.There was no significant difference between the coronary heart disease group and the control group in sex,age,the prevalence of hypertension,the prevalence of diabetes,FBG,smoking,drinking and so on(P>0.05).Body mass index(BMI): the coronary heart disease group was(23.74±2.13)(Kg/m2),and the control group was(22.83±2.09)(Kg/m2).The difference between the two groups was statistically significant(P<0.05).2.Comparison of blood lipid levels in coronary heart disease group and control group.HDL-C: the coronary heart disease group was(0.78±0.17)mmol/L,and the control group was(1.09±0.21)mmol/L.The difference between the two groups was statistically significant(P<0.05).LDL-C: the coronary heart disease group was(2.95±0.52)mmol/L,and the control group was(2.23±0.39)mmol/L.The difference between the two groups was statistically significant(P<0.05).There was no significant difference in TC and TG between the two groups(P>0.05).3.Blood lipid level and BMI comparison between subgroups of coronary heart diseaseHDL-C: the low risk group was(0.91±0.15)mmol/L,the middle risk group was(0.81±0.21)mmol/L,and the high risk group was(0.70±0.14).The difference of 22 groups was statistically significant(all P<0.05).LDL-C: the low risk group was(2.87±0.42)mmol/L,the middle risk group was(3.20±0.58)mmol/L and the high risk group was(3.13±0.54)mmol/L.The difference of the low risk group and the middle risk group and the high risk group were statistically significant(P<0.05).There was no statistical difference between the middle risk group and the high risk group(P>0.05).BMI: the low risk group was(23.88±2.13)(Kg/m2),the middle risk group was(24.99±2.05)(Kg/m2),and the high risk group was(25.06±2.21)(Kg/m2).The difference between the low risk group and the middle risk group and the high risk group was statistically significant(P<0.05).The difference was not statistically significant(P>0.05)in the middle risk group and the high risk group.There was no significant difference in TG and TC between the subgroups(P>0.05).4.comparison of AIP value between coronary heart disease group and control groupThe AIP value of the coronary heart disease group was (2.14±0.25),and the AIP value of the control group was(2.03±0.22),the difference was statistically significant(P<0.05).5.Comparison of AIP values between different subgroups of coronary heart diseaseAIP value: the low risk group was(2.10±0.18),the middle risk group was(2.21±0.20),the high risk group was(2.21±0.20),22 the difference was statistically significant(P<0.05).By linear regression analysis of SYNTAX score and AIP,there is a linear relationship between the two and the regression equation Y= 12.853+23.883 X,F=11.271,P=0.000,and the correlation coefficient is 0.315.Therefore,it can be preliminarily considered that the SYNTAX score will gradually increase with the increase of AIP.Multivariate linear regression analysis of variables affecting SYNTAX scores showed that AIP,LDL-C and BMI were positively correlated with SYNTAX scores,and HDL-C was negatively correlated with SYNTAX scores.Coclusions:AIP can reflect the severity of coronary artery disease and may be one of the independent risk factors of coronary atherosclerosis. |
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