Relationship Between Ambulatory Arterial Stiffness Index And Atherogenic Index Of Plasma And Coronary Heart Disease

Objective: With the improvement of the living level and changes inlifestyle, coronary atherosclerotic heart disease (coronary heart disease, CHD)of the disease incidence rate and the mortality rate are rising year by year, hasnow become the first cause of mortality and disability in crowd[1].Due to theearly symptoms of the most coronary heart disease are not typical, so difficultto diagnosis early. Although the coronary angiography can be visuallydiagnosis or exclusion of coronary heart disease, but it still belongs to theinvasive operation, difficult to spread in the crowd. Our study on therelationship between Ambulatory Arterial Stiffness Index (AASI) andAtherogenic Index of Plasma (AIP) and Coronary Heart Disease is given here.In order to clear the relationship Between AASI and AIP and CHD, To Providethe clinical evidence for the prevention and treatment of CHD.Methods:94patients (male54cases, female40cases), age40-86(64.33±10.11) years old with chest tightness, chest pain and suspected CHD wereselected in our department of cardiology in the hospital from2011January to2012December.94patients were taken the Coronary angiography,24-hourambulatory blood pressure (ABMP) and blood tests. the94patients underwentthe Coronary angiography with lesions involving the left main coronary artery(LM), left anterior descending (LAD),left circumflex artery (LCX), rightcoronary artery (RCA) counts were divided into the control group and theCHD group. According to the lesions involving the number of the coronaryarteries(significant left main calculation to involved in LAD, LCX), thecoronary atherosclerotic heart disease groups were divided into single vesseldisease group, double vessel disease group, and triple vessel disease group. Toanalyze the clinical data of94cases in the hospital, comparing the differencesof24hAASI, AASI during the day, AASI during the night and AIP.AIP and 24hAASI, AASI during the day, AASI during the night were analyzed bylinear correlation. The number of diseased coronary artery and24hAASI,AASI during the day, AASI during the night, AIP were analyzed by linearcorrelation.Results:1Comparison of the CHD group and the control group in general clinical dataThere were no significant differences in gender, age, BMI, the prevalenceof hypertension, the prevalence of diabetes, smoking rate, drinking rate,fasting blood-glucose of the control group and the CHD group (P＞0.05).2Comparison of the CHD group and the control group in Blood lipid indexThere were significant differences between the control group and theCHD group in the serum levels of TC,TG,HDL-C,LDL-C,(P＜0.05). TheCHD group TC, TG and LDL-C were higher than those in the control group,HDL-C was lower than that of control group.3Statistic of the24hAASI, AASI during the day, AASI during the night, AIPin the different subgroups：3.1There were significant differences in the single vessel disease group’s24hAASI(0.52±0.04), the double vessel disease group’s24hAASI(0.61±0.06),the triple vessel disease group’s24hAASI(0.70±0.12) and the control group’s24hAASI(0.38±0.11),(P＜0.01). SNK-q multiple comparison test showed that24hAASI in the control group, the single vessel disease group, the doublevessel disease group and the triple vessel disease group overall meandifferences were statistically significant (P <0.01).it can be thought of as withthe24hAASI was increased the number of diseased coronary artery increasedgradually.3.2There were significant differences in the single vessel disease group’sAASI during the day (0.55±0.09), the double vessel disease group’s AASIduring the day (0.62±0.11), the triple vessel disease group’s AASI during theday (0.72±0.18) and the control group’s AASI during the day (0.40±0.02),(P＜0.01). SNK-q multiple comparison test results show that except the single vessel disease group and the double vessel disease group, There weresignificant differences in every two groups. It Can be considered that AASIduring the day of the single vessel disease group and the double vessel diseasegroup is higher than the single vessel disease group and the triple vesseldisease group’s AASI during the day is the highest.3.3There were significant differences in the single vessel disease group’sAASI during the night (0.58±0.21), the double vessel disease group’s AASIduring the night (0.64±0.21), the triple vessel disease group’s AASI during thenight (0.63±0.21) and the control group’s AASI during the night (0.40±0.19),(P＜0.01). SNK-q multiple comparison test results show that there were nosignificant differences in any groups in the CHD group; it can be consideredthat AASI during the night of the CHD group is higher than the control group.3.4There were significant differences in the single vessel disease group’s AIP(0.27±0.13), the double vessel disease group’s AIP (0.28±0.12), the triplevessel disease group’s AIP (0.25±0.09) and the control group’s AIP(-0.17±0.15),(P＜0.01). SNK-q multiple comparison test results show thatthere were no significant difference in any groups in the CHD group, it can beconsidered that AIP of the CHD group is higher than the control group.4Correlation analysis4.1Linear regression showed that AIP correlated positively with24hAASI,AASI during the day, AASI during the night, Pearson correlation coefficientsare (r=0.541P＜0.01),(r=0.405P＜0.01),(r=0.451P＜0.01)．4.2Linear regression showed that the number of diseased coronary arterycorrelated positively with24hAASI, AASI during the day, AASI during thenight, AIP, Spearman correlation coefficients are (r=0.857P＜0.01),(r=0.699P＜0.01),(r=0.471P＜0.01),(r=0.685P＜0.01)．Conclusions: Increased risk of CHD as the24hAASI, AASI during theday, AASI during the night, AIP increased. Compared with AASI during theday, AASI during the night, AIP, the maximum value of correlationcoefficients was found between24hAASI and the number of diseasedcoronary artery correlated positively. As the larger24hAASI, CHD may be more extensive.