Application Value Of Arterial Spin Labeling In Ischemic Cerebral Infarction

Objective To investigate the value of three-dimensional arterial spin labeling(3D-ASL)in ischemic cerebral infarction.Methods Information about 106 hospitalized patients of this hospital who have suspected ischemic cerebral infarction was collected from March,2017 to January,2018,among whom,60 patients were finally diagnosed with ischemic cerebral infarction.MRI was performed within 72 hours after the stroke,including cerebral routine MR scanning,DWI,3D-TOF-MRA and 3D-ASL(PLD 1.5s and PLD 2.5s).Interobserver variability for ABS was assessed using Cohen's weighted Kappa statistic.Sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)for ABS were also determined.Sixty patients with ischemic cerebral infarction were divided into ATA group and non-ATA group.Two independent samples t-tests were used to compare NIHSS Scores on admission day,15 days after admission and the difference of score between admission day and 15 days after admission.Results The sensitivity,specificity,positive predictive value and negative predictive value of ABS in detecting intracranial arterial occlusion were 96.1%,91.2%,89.3% and 96.9%,respectively;ABS was highly consistent with MRA in the diagnosis of intracranial artery occlusion(?= 0.865,p <0.001).The NIHSS scores of ATA group and non-ATA group on admission day were 3.77 ± 1.910 and 3.07 ± 1.033,respectively.There was no significant difference on admission day between the two groups(p> 0.05).NIHSS scores of ATA group and non-ATA group were 1.19 ± 1.046,2.03 ± 0.906,NIHSS scores were significantly different between the two groups on 15 days after admission(p <0.05).There are significant differences between NIHSS scores on the admission day and those 15 days after admission,being 2.58 ± 1.285 and 1.03 ± 0.981 respectively(P <0.01).Conclusion 1.ABS on raw ASL image has a high level of sensitivity and specificity in the diagnosis of intracranial artery occlusion and has a high degree of consistency with the MRA diagnosis.2.ATA on ASL-CBF pseudo-color map can truthfully reflect the state of perfusion and provide imaging basis for the accurate determination of the prognosis and the short-term clinical evaluation of the patients.