Risk Factors Of Cerebral Small Vessel Disease Load And Its Relationship With Prognosis Of Acute Small Artery Occlusion Cerebral Infarction

Objectives Objective to explore the risk factors of cerebral small vessel disease burden in acute arteriolar occlusive cerebral infarction and its effect on prognosis of acute small artery occlusion cerebral infarction.Methods 69 cases of acute arteriolo occlusive cerebral infarction were selected as clinical subjects.The time span was 2 years from June 2015-2017 June.All patients were enrolled in the Chinese national stroke registration high resolution MRI subgroup of the Beijing Tiantan Hospital and the high resolution nuclear magnetic research project of the union hospital.The high-resolution magnetic resonance imaging(MRI)was retrospectively analyzed.According to the results of 3.0T MRI,two senior imageology physicians diagnosed the old lacunar infarction,the enlarged perivascular space,the leukoaraiosis and the intracerebral hemorrhage.According to the burden of cerebral small vessel disease,the score was 0 points(n=4),1 points(n=12),2 points(n=29),3 points(n=16),4 points(n=8).According to the National Institutes of Health Stroke Scale(NIHSS),we assessed the degree of neurological impairment during onset.6 months later,the same two neurosurgeon was assessed according to the modified Rankin scale(m RS)score to assess the degree of neurological impairment recovery.According to the improved RANKIN scale(Modified Rankin Scale,MRS)score,the score < 2(n=47)score was more than 2(n=22),and divided into good prognosis group and poor prognosis group.The old lacunar infarctions,enlarged perivascular spaces,leukoaraiosis and intracerebral microbleeds were respectively grouped.According to the risk factors of cerebrovascular disease collected during hospitalization,the indexes of hypertension,diabetes,hyperlipidemia,hyperhomocysteinemia and patients' general conditions including age,sex,smoking and drinking history were observed,and the auxiliary examination included electrocardiogram and dynamic electrocardiography,cervical vascular color doppler ultrasound and echocardiography.Graph,head MRI.The risk factors of cerebral small vascular disease were determined by chi square test.The risk factors of old lacunar infarction,enlarged perivascular space,leukoaraiosis,intracerebral hemorrhage,and the effect of acute cerebral infarction on the prognosis of cerebral infarction for 6 months were analyzed by chi square test.Chi square test,nonparametric rank sum test and multivariate logistic regression analysis were used to predict the 6 month prognosis of acute arteriolar occlusive cerebral infarction.All the results were statistically significant by bilateral test P<0.05.Results 1 there were no significant differences in gender,age,smoking,drinking,and basic diseases such as hypertension,diabetes,hyperlipidemia and hyperhomocysteinemia(P>0.05).2 the risk factors of old lacunar infarction,enlarged perivascular space,leukoaraiosis,intracerebral hemorrhage and the 6 month prognosis of acute cerebral infarction were statistically analyzed.The single factor analysis showed sex,age,smoking,drinking,and hypertension,diabetes,high blood fat.There was no statistical difference between the basic diseases such as hyperhomocysteinemia,such as hyperhomocysteinemia(P>0.05),and they had no statistically significant effect on the 6 month prognosis of acute arteriole occlusive cerebral infarction(P>0.05).3 the risk factors affecting the 6 month prognosis of acute arteriole occlusive cerebral infarction were no significant difference between sex,age,smoking,drinking,and basic diseases such as hypertension,diabetes,hyperlipidemia and hyperhomocysteinemia(P>0.05),and NIHSS evaluation at admission.There was a statistically significant difference between the groups(P<0.05),and there was a statistically significant difference between the group and the cerebrovascular disease load group(P<0.05).Multiple factor Logistic regression analysis: NIHSS score of [P=0.001,OR=1.648(95%CI(1.240-2.189)],[P=0.007,OR=2.632(95%CI(1.308-5.299)],indicating that The NIHSS score and the burden of cerebral small vessel disease were independent risk factors for the prognosis of 6 months after acute arteriolar occlusive infarction.Conclusions The NIHSS score and the burden of cerebral small vessel disease were independent risk factors for the prognosis of 6 months after acute arteriolar occlusive infarction.